MAPK signal pathways in the regulation of cell proliferation in mammalian cells

被引：2137

作者：

Zhang, W ^{[1
]}

Liu, HT ^{[1
]}

机构：

[1] Beijing Normal Univ, Coll Life Sci, Minist Educ, Key Lab Cell Proliferat & Regulat Biol, Beijing 100875, Peoples R China

来源：

CELL RESEARCH | 2002年 / 12卷 / 01期

关键词：

MAPK; ERK; JNK/SPAK; p38; cell proliferation; cross-talk;

D O I：

10.1038/sj.cr.7290105

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

MAPK families play an important role in complex cellular programs like proliferation, differentiation, development, transformation, and apoptosis. At least three MAPK families have been characterized: extracellular signal-regulated kinase (ERK), Jun kinase (JNK/SAPK) and p38 MAPK. The above effects are fulfilled by regulation of cell cycle engine and other cell proliferation related proteins. In this paper we discussed their functions and cooperation with other signal pathways in regulation of cell proliferation.

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页码：9 / 18

页数：10

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