An inverse correlation between serum leptin levels and hemoglobin Alc in patients with non-insulin dependent diabetes mellitus

被引：29

作者：

Moriya, M ^{[1
]}

Okumura, T ^{[1
]}

Takahashi, N ^{[1
]}

Yamagata, K ^{[1
]}

Motomura, W ^{[1
]}

Kohgo, Y ^{[1
]}

机构：

[1] Asahikawa Med Coll, Dept Internal Med 3, Asahikawa, Hokkaido 0788510, Japan

来源：

DIABETES RESEARCH AND CLINICAL PRACTICE | 1999年 / 43卷 / 03期

关键词：

leptin; NIDDM; HbAlc;

D O I：

10.1016/S0168-8227(99)00013-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We measured serum leptin concentrations in 70 patients with diabetes mellitus to investigate the relationship between serum leptin levels and glycemic control. A positive correlation between serum leptin levels and body mass index or plasma insulin was obtained as reported previously. The present study also demonstrated an inverse association of serum leptin levels with hemoglobin Ale (HbA1c). Multiple regression analysis revealed that HbA1c was an independent determinant of serum leptin levels. These results suggest that HbA1c may be a factor to influence serum leptin levels and that hyperglycemia for a long period or poorly controlled diabetes may reduce leptin levels. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：187 / 191

页数：5

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