Genome structure and chromosomal mapping of the gene for Fe65L2 interacting with Alzheimer's β-amyloid precursor protein

被引：11

作者：

Tanahashi, H ^{[1
]}

Tabira, T ^{[1
]}

机构：

[1] Natl Inst Neurosci, Div Demyelinating Dis & Aging, Kodaira, Tokyo 1878502, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1999年 / 258卷 / 02期

关键词：

D O I：

10.1006/bbrc.1999.0639

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recently we cloned the cDNA encoding human Fe65L2, which interacts with Alzheimer's beta-amyloid precursor protein (APP), The protein has one WW domain and two PID elements (Neurosci. Lett. (1999) 261., 143-146.). Here, we report the entire genome structure and the chromosomal mapping of the Fe65L2 gene. The gene is composed of thirteen coding exons distributed over 6 kb and the genomic organization is similar to another Fe65 member, Fe65 gene Two transcription start sites of the gene were found in a CpG island by primer extension analysis. Radiation hybrid mapping revealed that the Fe65L2 gene is on chromosome 5 between markers SHGC-9824 (D5S2374) and SHGC-8489 (D5S2569), Characterization of the Fe65L2 gene structure will be useful in the linkage analysis and search for mutations in the Fe65L2 gene in patients with Alzheimer's disease. (C) 1999 Academic Press.

引用

页码：385 / 389

页数：5

共 27 条

[1]

BLAIKIE P, 1994, J BIOL CHEM, V269, P32031

[2]

Borg JP, 1996, MOL CELL BIOL, V16, P6229

[3] The X11α protein slows cellular amyloid precursor protein processing and reduces Aβ40 and Aβ42 secretion [J].

Borg, JP ;

Yang, YN ;

De Taddéo-Borg, M ;

Margolis, B ;

Turner, RS .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (24) :14761-14766

[4]

BREATHNACH R, 1981, ANNU REV BIOCHEM, V50, P349, DOI 10.1146/annurev.bi.50.070181.002025

[5] WEIGHT MATRIX DESCRIPTIONS OF 4 EUKARYOTIC RNA POLYMERASE-II PROMOTER ELEMENTS DERIVED FROM 502 UNRELATED PROMOTER SEQUENCES [J].

BUCHER, P .

JOURNAL OF MOLECULAR BIOLOGY, 1990, 212 (04) :563-578

[6] Alzheimer's A beta(1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells [J].

Cook, DG ;

Forman, MS ;

Sung, JC ;

Leight, S ;

Kolson, DL ;

Iwatsubo, T ;

Lee, VMY ;

Doms, RW .

NATURE MEDICINE, 1997, 3 (09) :1021-1023

[7] Estimation of the genetic contribution of presenilin-1 and -2 mutations in a population based study of presenile Alzheimer disease [J].

Cruts, M ;

van Duijn, CM ;

Backhovens, H ;

Van den Broeck, M ;

Wehnert, A ;

Serneels, S ;

Sherrington, R ;

Hutton, M ;

Hardy, J ;

St George-Hyslop, PH ;

Hofman, A ;

Van Broeckhoven, C .

HUMAN MOLECULAR GENETICS, 1998, 7 (01) :43-51

[8]

Cruts M, 1998, HUM MUTAT, V11, P183, DOI 10.1002/(SICI)1098-1004(1998)11:3<183::AID-HUMU1>3.3.CO

[9]

2-M

[10] Fe65L2:: a new member of the Fe65 protein family interacting with the intracellular domain of the Alzheimer's β-amyloid precursor protein [J].

Duilio, A ;

Faraonio, R ;

Minopoli, G ;

Zambrano, N ;

Russo, T .

BIOCHEMICAL JOURNAL, 1998, 330 :513-519

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