TAFs mediate transcriptional activation and promoter selectivity

被引：322

作者：

Verrijzer, CP

Tjian, R

机构：

[1] Howard Hughes Medical Institute, Dept. of Molecular and Cell Biology, University of California, Berkeley

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1996年 / 21卷 / 09期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0968-0004(96)10044-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The TATA-binding protein (TBP)-associated factors (TAFs) of TFIID play a central role in RNA polymerase II transcriptional regulation. Some TAFs can function as coactivators that mediate the activation signal from enhancer-bound regulators. In addition, interactions between selected TAFs and core elements direct promoter selectivity by RNA polymerase II.

引用

收藏

页码：338 / 342

页数：5

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