Exosomes mediate the cell-to-cell transmission of IFN-α-induced antiviral activity

被引：452

作者：

Li, Jianhua ^{[1
]}

Liu, Kuancheng ^{[1
]}

Liu, Yang ^{[1
]}

Xu, Yan ^{[1
]}

Zhang, Fei ^{[1
]}

Yang, Huijuan ^{[1
]}

Liu, Jiangxia ^{[1
]}

Pan, Tingting ^{[1
]}

Chen, Jieliang ^{[1
]}

Wu, Min ^{[2
]}

Zhou, Xiaohui ^{[3
]}

Yuan, Zhenghong ^{[1
,2
]}

机构：

[1] Fudan Univ, Sch Basic Med Sci, Shanghai Med Coll, Key Lab Med Mol Virol, Shanghai 200433, Peoples R China

[2] Fudan Univ, Res Unit, Shanghai Publ Hlth Clin Ctr, Shanghai 200433, Peoples R China

[3] Fudan Univ, Ctr Lab Anim, Shanghai Publ Hlth Clin Ctr, Shanghai 200433, Peoples R China

来源：

NATURE IMMUNOLOGY | 2013年 / 14卷 / 08期

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

HEPATITIS-B-VIRUS; INTERFERON-INDUCED TRANSFER; DENDRITIC CELLS; INTERCELLULAR COMMUNICATION; VIRAL RESISTANCE; INNATE IMMUNITY; INFECTED-CELLS; CHIMERIC MICE; TUMOR-GROWTH; C VIRUS;

D O I：

10.1038/ni.2647

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The cell-to-cell transmission of viral resistance is a potential mechanism for amplifying the interferon-induced antiviral response. In this study, we report that interferon-alpha (IFN-alpha) induced the transfer of resistance to hepatitis B virus (HBV) from nonpermissive liver nonparenchymal cells (LNPCs) to permissive hepatocytes via exosomes. Exosomes from IFN-alpha-treated LNPCs were rich in molecules with antiviral activity. Moreover, exosomes from LNPCs were internalized by hepatocytes, which mediated the intercellular transfer of antiviral molecules. Finally, we found that exosomes also contributed to the antiviral response of IFN-alpha to mouse hepatitis virus A59 and adenovirus in mice. Thus, we propose an antiviral mechanism of IFN-alpha activity that involves the induction and intercellular transfer of antiviral molecules via exosomes.

引用

页码：793 / +

页数：13

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