MR three-dimensional molecular imaging of intramural biomarkers with targeted nanoparticles

被引：26

作者：

Cyrus, Tillmann

Abendschein, Dana R.

Caruthers, Shelton D.

Harris, Thomas D.

Glattauer, Veronica

Werkmeister, Jerome A.

Ramshaw, John A. M.

Wickline, Samuel A.

Lanza, Gregory M.

机构：

[1] Washington Univ, Sch Med, Div Cardiol, St Louis, MO 63110 USA

[2] Philips Med Syst, Cleveland, OH USA

[3] Bristol Myers Squibb Med Imaging, Billerica, MA USA

来源：

JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE | 2006年 / 8卷 / 03期

关键词：

magnetic resonance imaging; molecular imaging; nanoparticles; integrins; collagen III; angioplasty; restenosis;

D O I：

10.1080/10976640600580296

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In this study, porcine carotid arteries were subjected to balloon overstretch injury followed by local delivery of paramagnetic nanoparticles targeted to alpha(v)beta(3)-integrin expressed by smooth muscle cells or collagen III within the extracellular matrix. Carotid T-1-weighted angiography and vascular imaging was performed at 1.5T. While MR angiograms were indistinguishable between control and targeted vessel segments, alpha(v)beta(3)-integrin-and collagen III-targeted nanoparticles spatially delineated patterns and volumes of stretch injury. In conclusion, MR molecular imaging with alpha(v)beta(3)-integrin or collagen III-targeted nanoparticles enables the non-invasive, three-dimensional characterization of arterial pathology unanticipated from routine angiography.

引用

收藏

页码：535 / 541

页数：7

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