CRH and the immune system

被引:176
作者
Karalis, K
Louis, JM
Bae, D
Hilderbrand, H
Majzoub, JA
机构
关键词
corticotropin-releasing hormone; neuroendocrine-immune interaction; hypothalamic-pituitary-adrenal axis;
D O I
10.1016/S0165-5728(96)00178-6
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Inflammatory cytokines released during immune system activation can stimulate the hypothalamic-pituitary-adrenal axis and cause increased secretion of corticotropin-releasing hormone (CRH), adrenocorticotropin and glucocorticoids. Identification of CRH peptide and mRNA, as well as its receptors in immune tissues, suggested a role for this peptide as a mediator of the neuroendocrine-immune interactions. Experimental evidence suggests that CRH may modulate the immune and inflammatory responses via two pathways: an antiinflammatory one operated by centrally released CRH, most likely through stimulation of glucocorticoid and catecholamine release, and one proinflammatory, through direct action of peripherally released CRH. This review highlights these concepts. In addition preliminary data on immune activation and inflammatory response in CRH-deficient mice created in our laboratory are discussed.
引用
收藏
页码:131 / 136
页数:6
相关论文
共 87 条
  • [1] CORTICOTROPIN-RELEASING FACTOR MESSENGER-RNA IN RAT THYMUS AND SPLEEN
    AIRD, F
    CLEVENGER, CV
    PRYSTOWSKY, MB
    REDEI, E
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (15) : 7104 - 7108
  • [2] CORTICOSTERONE - NARROW RANGE REQUIRED FOR NORMAL BODY AND THYMUS WEIGHT AND ACTH
    AKANA, SF
    CASCIO, CS
    SHINSAKO, J
    DALLMAN, MF
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1985, 249 (05): : R527 - R532
  • [3] INTERLEUKIN-1-BETA ENHANCES CORTICOSTERONE SECRETION BY ACTING DIRECTLY ON THE RAT ADRENAL-GLAND
    ANDREIS, PG
    NERI, G
    BELLONI, AS
    MAZZOCCHI, G
    KASPRZAK, A
    NUSSDORFER, GG
    [J]. ENDOCRINOLOGY, 1991, 129 (01) : 53 - 57
  • [4] CORTICOTROPIN-RELEASING HORMONE MODULATES CYTOKINES RELEASE IN CULTURED HUMAN PERIPHERAL-BLOOD MONONUCLEAR-CELLS
    ANGIONI, S
    PETRAGLIA, F
    GALLINELLI, A
    COSSARIZZA, A
    FRANCESCHI, C
    MUSCETTOLA, M
    GENAZZANI, AD
    SURICO, N
    GENAZZANI, AR
    [J]. LIFE SCIENCES, 1993, 53 (23) : 1735 - 1742
  • [5] RECEPTOR-MEDIATED IMMUNOMODULATION BY CORTICOTROPIN-RELEASING FACTOR
    AUDHYA, T
    JAIN, R
    HOLLANDER, CS
    [J]. CELLULAR IMMUNOLOGY, 1991, 134 (01) : 77 - 84
  • [6] BAE DS, 1996, INT C END SAN FRANC
  • [7] BANKS WA, 1991, J PHARMACOL EXP THER, V259, P988
  • [8] THE IMMUNE-HYPOTHALAMIC-PITUITARY-ADRENAL AXIS
    BATEMAN, A
    SINGH, A
    KRAL, T
    SOLOMON, S
    [J]. ENDOCRINE REVIEWS, 1989, 10 (01) : 92 - 112
  • [9] ADRENALECTOMY SENSITIZES MICE TO THE LETHAL EFFECTS OF INTERLEUKIN-1 AND TUMOR NECROSIS FACTOR
    BERTINI, R
    BIANCHI, M
    GHEZZI, P
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1988, 167 (05) : 1708 - 1712
  • [10] IMMUNOREGULATORY FEEDBACK BETWEEN INTERLEUKIN-1 AND GLUCOCORTICOID HORMONES
    BESEDOVSKY, H
    DELREY, A
    SORKIN, E
    DINARELLO, CA
    [J]. SCIENCE, 1986, 233 (4764) : 652 - 654