Spatial expression of sonic hedgehog in the lung epithelium during branching morphogenesis

被引：55

作者：

Urase, K

Mukasa, T

Igarashi, H

Ishii, Y

Yasugi, S

Momoi, MY

Momoi, T

机构：

[1] NCNP, NATL INST NEUROSCI, DIV DEV & DIFFERENTIAT, KODAIRA, TOKYO 187, JAPAN

[2] JICHI MED SCH, DEPT PEDIAT, MINAMI KAWACHI, TOCHIGI 32904, JAPAN

[3] TOKYO METROPOLITAN UNIV, FAC SCI, DEPT BIOL, HACHIOJI, TOKYO 19203, JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1996年 / 225卷 / 01期

关键词：

D O I：

10.1006/bbrc.1996.1147

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sonic hedgehog (Shh), a homologue of Drosophila hedgehog, was specifically expressed in lung epithelium during branching morphogenesis, but was not uniformly expressed in lung epithelium. Shh was intensely expressed in the distal tips of the bronchial tubes during branching morphogenesis, and Shh was localized on the apical side of the epithelium. On the other hand, Bmp-4, one of the target genes of Shh, was also specifically expressed in the epithelium at the branching point. These results suggest that Shh and Bmp-4 are involved in the branching morphogenesis of lung epithelium. (C) 1996 Academic Press, Inc.

引用

页码：161 / 166

页数：6

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