Preparation of poly(L-lactic acid) nano- and micro-particles using supercritical antisolvent

被引：5

作者：

Choi, S

Lee, K

Kim, H

机构：

[1] Seoul Natl Univ, Sch Chem Engn, Seoul 151744, South Korea

[2] Seoul Natl Univ, Inst Chem Proc, Seoul 151744, South Korea

来源：

JOURNAL OF CHEMICAL ENGINEERING OF JAPAN | 2005年 / 38卷 / 08期

关键词：

aerosol solvent extraction system; poly(L-Lactic acid); supercritical fluid; carbon dioxide;

D O I：

10.1252/jcej.38.571

中图分类号：

TQ [化学工业];

学科分类号：

0817 [化学工程与技术];

摘要：

The objective of this study was to find the effect of the initial droplet size in the ASES (aerosol solvent extraction system) process. We prepared poly(L-lactic acid) (PLLA) nano- and micro-particles using ASES process. The experiments were carried out on various conditions. We got PLLA particles that had mean particle diameter from 0.54 to 1.28 mu m. And we calculated theoretical initial droplet size with the equation derived by Lorenzetto and Lefebvre and investigated the relation between the initial droplet size and particle size. The results show that there is a linear relationship between the initial droplet size and particle diameter.

引用

页码：571 / 577

页数：7

共 22 条

[1]

Biodegradable semi-crystalline comb polyesters influence the microsphere production by means of a supercritical fluid extraction technique (ASES) [J].