The evolving field of induced pluripotency: Recent progress and future challenges

被引：32

作者：

Sommer, Cesar A.

Mostoslavsky, Gustavo ^{[1
,2
]}

机构：

[1] Boston Univ, Sch Med, Gastroenterol Sect, Dept Med, Boston, MA 02118 USA

[2] Boston Univ, Sch Med, Ctr Regenerat Med CReM, Boston, MA 02118 USA

来源：

JOURNAL OF CELLULAR PHYSIOLOGY | 2013年 / 228卷 / 02期

关键词：

EMBRYONIC STEM-CELLS; HUMAN SOMATIC-CELLS; IPS CELLS; HUMAN FIBROBLASTS; GENE-TRANSFER; SENDAI-VIRUS; DIRECTED DIFFERENTIATION; EPIGENETIC MEMORY; LENTIVIRAL VECTOR; COPY NUMBER;

D O I：

10.1002/jcp.24155

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

The derivation of patient-specific pluripotent cell lines through the introduction of a few transcription factors into somatic cells has opened new avenues for the study and treatment of human disorders. Induced pluripotent stem cells (iPSCs) and their derivatives offer a unique platform for disease modeling, drug discovery and toxicology, as well as an invaluable source of cells for regenerative therapies. Here, we provide an overview of the various strategies currently available for iPSC generation, highlighting recent advances and discussing some of the challenges faced in harnessing the true potential of iPSCs for biomedical research and therapeutic applications. J. Cell. Physiol. 228: 267275, 2013. (c) 2012 Wiley Periodicals, Inc.

引用

收藏

页码：267 / 275

页数：9

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