Novel cytotoxic, alkylated hydroquinones from Lannea welwitschii

被引：30

作者：

Groweiss, A

Cardellina, JH

Pannell, LK

Uyakul, D

Kashman, Y

Boyd, MR

机构：

[1] NCI, FREDERICK CANC RES & DEV CTR, DIV CANC TREATMENT, LAB DRUG DISCOVERY RES & DEV, FREDERICK, MD 21702 USA

[2] NIDDKD, ANALYT CHEM LAB, BETHESDA, MD 20892 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 1997年 / 60卷 / 02期

关键词：

D O I：

10.1021/np960435t

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two novel natural products, lanneaquinol(1) and 2'(R)-hydroxylanneaquinol (2), were isolated from the organic extract of the plant Lannea welwitschii (Hiern) Engl. Their structures were solved by spectroanalytical methods and confirmed by comparison to synthetic models. The absolute configuration of 2 was determined by the modified Mosher method. Both compounds exhibited modest cytotoxicity against the NCI panel of 60 human tumor cell lines. The structures of two isomeric 4,5-dihydroxy-5-alkyl-2-cyclohexenones (7 and 8), which appear to be biogenetic precursors of 1 and 2, were also elucidated.

引用

页码：116 / 121

页数：6

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