Heart failure and diabetes: metabolic alterations and therapeutic interventions: a state-of-the-art review from the Translational Research Committee of the Heart Failure Association-European Society of Cardiology

被引：226

作者：

Maack, Christoph ^{[1
]}

Lehrke, Michael ^{[2
]}

Backs, Johannes ^{[3
]}

Heinzel, Frank R. ^{[4
]}

Hulot, Jean-Sebastien ^{[5
,6
,7
]}

Marx, Nikolaus ^{[2
]}

Paulus, Walter J. ^{[8
]}

Rossignol, Patrick ^{[9
,10
]}

Taegtmeyer, Heinrich ^{[11
]}

Bauersachs, Johann ^{[12
]}

Bayes-Genis, Antoni ^{[13
,14
,15
]}

Brutsaert, Dirk ^{[16
]}

Bugger, Heiko ^{[17
]}

Clarke, Kieran ^{[18
]}

Cosentino, Francesco ^{[19
,20
]}

De Keulenaer, Gilles ^{[21
]}

Dei Cas, Alessandra ^{[22
,23
]}

Gonzalez, Arantxa ^{[24
,25
]}

Huelsmann, Martin ^{[26
]}

Iaccarino, Guido ^{[27
]}

Lunde, Ida Gjervold ^{[28
,29
]}

Lyon, Alexander R. ^{[30
,31
]}

Pollesello, Piero ^{[32
]}

Rena, Graham ^{[33
]}

Riksen, Niels P. ^{[34
]}

Rosano, Giuseppe ^{[35
,36
]}

Staels, Bart ^{[37
,38
,39
,40
]}

van Laake, Linda W. ^{[41
,42
]}

Wanner, Christoph ^{[43
]}

Farmakis, Dimitrios ^{[44
]}

Filippatos, Gerasimos ^{[44
]}

Ruschitzka, Frank ^{[45
]}

Seferovic, Petar ^{[46
]}

de Boer, Rudolf A. ^{[47
]}

Heymans, Stephane ^{[48
,49
,50
]}

机构：

[1] Univ Clin Wurzburg, Comprehens Heart Failure Ctr, Wurzburg, Germany

[2] Univ Hosp Aachen, Dept Internal Med 1, Aachen, Germany

[3] Heidelberg Univ, Dept Mol Cardiol & Epigenet, Heidelberg, Germany

[4] Charite, Dept Cardiol, Berlin, Germany

[5] Paris Cardiovasc Res Ctr PARCC, INSERM UMR970, CIC 1418, Paris, France

[6] F CRIN INI CRCT Cardiovasc & Renal Clin Trialists, Paris, France

[7] Hop Europeen Georges Pompidou, AP HP, Paris, France

[8] Vrije Univ Amsterdam Med Ctr, Dept Physiol, Amsterdam, Netherlands

[9] Univ Lorraine, CHRU Nancy, Inserm U1116, Ctr Invest Clin Plurithemat 14 33, Nancy, France

[10] F CRIN INI CRCT Cardiovasc & Renal Clin Trialists, Nancy, France

[11] Univ Texas Hlth Sci Ctr Houston, McGovern Med Sch, Dept Internal Med, Houston, TX 77030 USA

[12] Hannover Med Sch, Dept Cardiol & Angiol, Hannover, Germany

[13] Hosp Badalona Germans Trias & Pujol, CIBERCV, Heart Failure Unit, Badalona, Spain

[14] Hosp Badalona Germans Trias & Pujol, CIBERCV, Serv Cardiol, Badalona, Spain

[15] Univ Autonoma Barcelona, Dept Med, Barcelona, Spain

[16] Univ Antwerp, Antwerp, Belgium

[17] Univ Freiburg, Ctr Heart, Cardiol & Angiol, Freiburg, Germany

[18] Univ Oxford, Dept Physiol Anat & Genet, Oxford, England

[19] Karolinska Inst, Cardiol Unit, Dept Med Solna, Stockholm, Sweden

[20] Karolinska Univ Hosp, Stockholm, Sweden

[21] Univ Antwerp, Lab Physiopharmacol, Antwerp, Belgium

[22] Univ Parma, Dept Med & Surg, Endocrinol & Metab, Parma, Italy

[23] Azienda Osped Univ Parma, Div Endocrinol & Metab Dis, Parma, Italy

[24] Univ Navarra, Ctr Appl Med Res, Program Cardiovasc Dis, Pamplona, Spain

[25] Carlos III Inst Hlth, CIBERCV, Madrid, Spain

[26] Med Univ Vienna, Dept Med 2, Div Cardiol, Vienna, Austria

[27] Univ Salerno, Dept Med Surg & Dent, Baronissi, Italy

[28] Oslo Univ Hosp, Inst Expt Med Res, Oslo, Norway

[29] Univ Oslo, Oslo, Norway

[30] Royal Brompton Hosp, Cardiovasc Res Ctr, London, England

[31] Imperial Coll London, Natl Heart & Lung Inst, London, England

[32] Univ Helsinki, Fac Med, Helsinki, Finland

[33] Univ Dundee, Ninewells Hosp & Med Sch, Div Mol & Clin Med, Dundee, Scotland

[34] Radboud Univ Nijmegen, Med Ctr, Dept Internal Med, Nijmegen, Netherlands

[35] Univ London, St Georges Hosp NHS Trust, Cardiovasc Clin Acad Grp, London, England

[36] IRCCS San Raffaele Roma, Rome, Italy

[37] Univ Lille, EGID, Lille, France

[38] INSERM, U1011, Lille, France

[39] Inst Pasteur, Lille, France

[40] Univ Hosp CHU Lille, Lille, France

[41] Univ Med Ctr Utrecht, Dept Cardiol, Heart & Lungs Div, Utrecht, Netherlands

[42] Univ Med Ctr Utrecht, Regenerat Med Ctr, Utrecht, Netherlands

[43] Wurzburg Univ Clin, Wurzburg, Germany

[44] Natl & Kapodistrian Univ Athens, Athens Univ Hosp Attikon, Heart Failure Unit, Athens, Greece

[45] Univ Hosp Zurich, Univ Heart Ctr, Zurich, Switzerland

[46] Univ Belgrade, Med Ctr, Dept Cardiol, Belgrade, Serbia

[47] Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands

[48] Maastricht Univ, Med, Cardiovasc Res Inst Maastricht, Dept Cardiol, Maastricht, Netherlands

[49] Netherlands Heart Inst, Utrecht, Netherlands

[50] Leuven Univ, Dept Cardiovasc Sci, Leuven, Belgium

来源：

EUROPEAN HEART JOURNAL | 2018年 / 39卷 / 48期

基金：

美国国家卫生研究院;

关键词：

PRESERVED EJECTION FRACTION; COTRANSPORTER; 2; INHIBITION; IMPROVES CARDIAC-FUNCTION; GLUCAGON-LIKE PEPTIDE-1; MYOCARDIAL TRIGLYCERIDE CONTENT; VENTRICULAR DIASTOLIC FUNCTION; CARDIOVASCULAR OUTCOMES; DOUBLE-BLIND; KETONE-BODIES; THIAZOLIDINEDIONE THERAPY;

D O I：

10.1093/eurheartj/ehy596

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

引用

页码：4243 / +

页数：15

共 151 条

[1]

Metformin Use and Mortality in Ambulatory Patients With Diabetes and Heart Failure [J].

Aguilar, David ;

Chan, Wenyaw ;

Bozkurt, Biykem ;

Ramasubbu, Kumudha ;

Deswal, Anita .

CIRCULATION-HEART FAILURE, 2011, 4 (01) :53-58

[2]

Relationship of Hemoglobin A1C and Mortality in Heart Failure Patients With Diabetes [J].

Aguilar, David ;

Bozkurt, Biykem ;

Ramasubbu, Kumudha ;

Deswal, Anita .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2009, 54 (05) :422-428

[3]

The Effect of Metformin on Diastolic Function in Patients Presenting with ST-Elevation Myocardial Infarction [J].

Al Ali, Lawien ;

Hartman, Minke T. ;

Lexis, Chris P. H. ;

Hummel, Yoran M. ;

Lipsic, Erik ;

van Melle, Joost P. ;

van Veldhuisen, Dirk J. ;

Voors, Adriaan A. ;

van der Horst, Iwan C. C. ;

van der Harst, Pim .

PLOS ONE, 2016, 11 (12)

[4]

The Global Health and Economic Burden of Hospitalizations for Heart Failure Lessons Learned From Hospitalized Heart Failure Registries [J].

Ambrosy, Andrew P. ;

Fonarow, Gregg C. ;

Butler, Javed ;

Chioncel, Ovidiu ;

Greene, Stephen J. ;

Vaduganathan, Muthiah ;

Nodari, Savina ;

Lam, Carolyn S. P. ;

Sato, Naoki ;

Shah, Ami N. ;

Gheorghiade, Mihai .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2014, 63 (12) :1123-1133

[5]

The Failing Heart Relies on Ketone Bodies as a Fuel [J].

Aubert, Gregory ;

Martin, Ola J. ;

Horton, Julie L. ;

Lai, Ling ;

Vega, Rick B. ;

Leone, Teresa C. ;

Koves, Timothy ;

Gardell, Stephen J. ;

Krueger, Marcus ;

Hoppel, Charles L. ;

Lewandowski, E. Douglas ;

Crawford, Peter A. ;

Muoio, Deborah M. ;

Kelly, Daniel P. .

CIRCULATION, 2016, 133 (08) :698-705

[6]

Empagliflozin decreases myocardial cytoplasmic Na+ through inhibition of the cardiac Na+/H+ exchanger in rats and rabbits [J].

Baartscheer, Antonius ;

Schumacher, Cees A. ;

Wust, Rob C. I. ;

Fiolet, Jan W. T. ;

Stienen, Ger J. M. ;

Coronel, Ruben ;

Zuurbier, Coert J. .

DIABETOLOGIA, 2017, 60 (03) :568-573

[7]

Metformin and Myocardial Injury in Patients With Diabetes and ST-Segment Elevation Myocardial Infarction: A Propensity Score Matched Analysis [J].

Basnet, Suresh ;

Kozikowski, Andrzej ;

Makaryus, Amgad N. ;

Pekmezaris, Renee ;

Zeltser, Roman ;

Akerman, Meredith ;

Lesser, Martin ;

Wolf-Klein, Gisele .

JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2015, 4 (10)

[8]

Challenging aspects of treatment strategies in heart failure with preserved ejection fraction: "Why did recent clinical trials fail?" [J].

Becher, Peter Moritz ;

Fluschnik, Nina ;

Blankenberg, Stefan ;

Westermann, Dirk .

WORLD JOURNAL OF CARDIOLOGY, 2015, 7 (09) :544-554

[9]

Evidence for Intramyocardial Disruption of Lipid Metabolism and Increased Myocardial Ketone Utilization in Advanced Human Heart Failure [J].

Bedi, Kenneth C., Jr. ;

Snyder, Nathaniel W. ;

Brandimarto, Jeffrey ;

Aziz, Moez ;

Mesaros, Clementina ;

Worth, Andrew J. ;

Wang, Linda L. ;

Javaheri, Ali ;

Blair, Ian A. ;

Margulies, Kenneth B. ;

Rame, J. Eduardo .

CIRCULATION, 2016, 133 (08) :706-716

[10]

Benbow A, 2001, BRIT MED J, V322, P236

← 1 2 3 4 5 6 7 8 9 10 →