GABA-mediated representation of temporal information in rat barrel cortex

被引:8
作者
Ajima, A
Matsuda, Y
Ohki, K
Kim, DS
Tanaka, S
机构
[1] RIKEN, Brain Sci Inst, Lab Neural Modeling, Wako, Saitama 3510198, Japan
[2] JST, PRESTO, Wako, Saitama 3510198, Japan
[3] Univ Tokyo, Sch Med, Dept Physiol, Tokyo 113, Japan
[4] Univ Minnesota, Sch Med, Ctr Magnet Resonance Res, Minneapolis, MN 55455 USA
关键词
barrel cortex; GABA; inhibition; intrinsic optical imaging; rat; temporal information;
D O I
10.1097/00001756-199906230-00033
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
TEMPORAL sequences of inputs to the rat whiskers are thought to be important to recognize the environment of the rat. In this study, we applied combined stimulations to neighboring whiskers D1 and D2, and the cortical activities evoked in the rat barrel cortex were measured using the intrinsic optical imaging technique. The timing of stimulation to neighboring whiskers affected the evoked cortical activities: the cortical activity evoked by in-phase stimulation to D1 and D2 was significantly stronger than that evoked by out-of-phase stimulation. In order to elucidate the mechanism underlying this phenomenon, the effect of blockade of cortical inhibitory circuits was examined. Iontophoretic application of bicuculline or saclofen (GABA-A or GABA-B antagonist) increased the evoked cortical activities and diminished the difference in activities obtained with in-phase and anti-phase stimulation. These results suggest that local inhibitory circuits play a critical role in coding temporal information of whisker stimulation. NeuroReport 10:1973-1979 (C) 1999 Lippincott Williams & Wilkins.
引用
收藏
页码:1973 / 1979
页数:7
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