Exploring a new twist on tumor metastasis

被引：228

作者：

Yang, Jing

Mani, Sendurai A.

Weinberg, Robert A.

机构：

[1] MIT, Whitehead Inst Biomed Res, Cambridge Ctr, Cambridge, MA 02139 USA

[2] MIT, Dept Biol, Cambridge, MA 02139 USA

来源：

CANCER RESEARCH | 2006年 / 66卷 / 09期

关键词：

D O I：

10.1158/0008-5472.CAN-05-3850

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Unraveling the genetic programs that drive -metastasis may offer insights into how to limit or prevent this deadly aspect of cancer progression. Our recent studies indicate that tumor cell metastasis involves the activity of the transcription factor, Twist, which regulates epithelial-mesenchymal transition and early embryonic morphogenesis. Here, we review the Twist signaling pathway during normal development and discuss how the transcription factor Twist and the epithelial-mesenchymal transition program impinge their biological functions during tumor metastasis.

引用

收藏

页码：4549 / 4552

页数：4

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