Identification of α1A-adrenoceptor selective antagonists for the treatment of benign prostatic hyperplasia

被引:15
作者
Lagu, B [1 ]
机构
[1] RW Johnson Pharmaceut Res Inst, Raritan, NJ 08869 USA
关键词
D O I
10.1358/dof.2001.026.08.662740
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
[No abstract available]
引用
收藏
页码:757 / 765
页数:9
相关论文
共 49 条
[1]   DIHYDROPYRIMIDINE CALCIUM-CHANNEL BLOCKERS - 2-HETEROSUBSTITUTED 4-ARYL-1,4-DIHYDRO-6-METHYL-5-PYRIMIDINECARBOXYLIC ACID-ESTERS AS POTENT MIMICS OF DIHYDROPYRIDINES [J].
ATWAL, KS ;
ROVNYAK, GC ;
SCHWARTZ, J ;
MORELAND, S ;
HEDBERG, A ;
GOUGOUTAS, JZ ;
MALLEY, MF ;
FLOYD, DM .
JOURNAL OF MEDICINAL CHEMISTRY, 1990, 33 (05) :1510-1515
[2]   In vitro and in vivo evaluation of dihydropyrimidinone C-5 amides as potent and selective α1A receptor antagonists for the treatment of benign prostatic hyperplasia [J].
Barrow, JC ;
Nantermet, PG ;
Selnick, HG ;
Glass, KL ;
Rittle, KE ;
Gilbert, KF ;
Steele, TG ;
Homnick, CF ;
Freidinger, RM ;
Ransom, RW ;
Kling, P ;
Reiss, D ;
Broten, TP ;
Schorn, TW ;
Chang, RSL ;
O'Malley, SS ;
Olah, TV ;
Ellis, JD ;
Barrish, A ;
Kassahun, K ;
Leppert, P ;
Nagarathnam, D ;
Forray, C .
JOURNAL OF MEDICINAL CHEMISTRY, 2000, 43 (14) :2703-2718
[3]  
BARROW JC, 2000, BIOORG MED CHEM LETT, V10, P2705
[4]   Toward the development of α1a adrenergic receptor antagonists [J].
Bock, MG ;
Patane, MA .
ANNUAL REPORTS IN MEDICINAL CHEMISTRY, VOL 35, 2000, 35 :221-230
[5]  
Broten T, 1999, FASEB J, V13, pA142
[6]   In vitro studies on L-771,688 (SNAP 6383), a new potent and selective α1A-adrenoceptor antagonist [J].
Chang, RSL ;
Chen, TB ;
O'Malley, SS ;
Pettibone, DJ ;
DiSalvo, J ;
Francis, B ;
Bock, MG ;
Freidinger, R ;
Nagarathnam, D ;
Miao, SW ;
Shen, QR ;
Lagu, B ;
Dhar, TGM ;
Tyagarajan, S ;
Marzabadi, MR ;
Wong, WC ;
Gluchowski, C ;
Forray, C .
EUROPEAN JOURNAL OF PHARMACOLOGY, 2000, 409 (03) :301-312
[7]   Inhibition by tamsulosin of tension responses of human hyperplastic prostate to electrical field stimulation [J].
Chueh, SC ;
Guh, JH ;
Chen, J ;
Lai, MK ;
Ko, FN ;
Teng, CM .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1996, 305 (1-3) :177-180
[8]   Design and synthesis of novel α1a adrenoceptor-selective antagonists.: 2.: Approaches to eliminate opioid agonist metabolites via modification of linker and 4-methoxycarbonyl-4-phenylpiperidine moiety [J].
Dhar, TGM ;
Nagarathnam, D ;
Marzabadi, MR ;
Lagu, B ;
Wong, WC ;
Chiu, G ;
Tyagarajan, S ;
Miao, SW ;
Zhang, FQ ;
Sun, WY ;
Tian, D ;
Shen, QR ;
Zhang, J ;
Wetzel, JM ;
Forray, C ;
Chang, RSL ;
Broten, TP ;
Schorn, TW ;
Chen, TB ;
O'Malley, S ;
Ransom, R ;
Schneck, K ;
Bendesky, R ;
Harrell, CM ;
Vyas, KP ;
Zhang, KY ;
Gilbert, J ;
Pettibone, DJ ;
Patane, MA ;
Bock, MG ;
Freidinger, RM ;
Gluchowski, C .
JOURNAL OF MEDICINAL CHEMISTRY, 1999, 42 (23) :4778-4793
[9]  
Forray, 1999, Expert Opin Investig Drugs, V8, P2073, DOI 10.1517/13543784.8.12.2073
[10]  
FORRAY C, 1994, MOL PHARMACOL, V45, P703