Cellular and molecular mechanisms regulating neuronal growth by brain-derived neurotrophic factor

被引：160

作者：

Gonzalez, Andres ^{[1
,2
]}

Moya-Alvarado, Guillermo ^{[1
,2
]}

Gonzalez-Billaut, Christian ^{[3
,4
]}

Bronfman, Francisca C. ^{[1
,2
]}

机构：

[1] Pontificia Univ Catolica Chile, Dept Physiol, Fac Biol Sci, MINREB, Santiago, Chile

[2] Pontificia Univ Catolica Chile, Dept Physiol, Fac Biol Sci, Ctr Ageing & Regenerat CARE UC, Santiago, Chile

[3] Univ Chile, Fac Sci, Dept Biol, Lab Cell & Neuronal Dynam, Santiago, Chile

[4] Gerosci Ctr Brain Hlth & Metab, Santiago, Chile

来源：

CYTOSKELETON | 2016年 / 73卷 / 10期

关键词：

BDNF; dendritic growth; signaling; cytoskeleton dynamics; membrane trafficking; RETINAL GANGLION-CELLS; CENTRAL-NERVOUS-SYSTEM; SMALL GTPASE RAB17; P75; RECEPTOR; RETROGRADE TRANSPORT; SIGNALING ENDOSOMES; TRKB RECEPTORS; RHO-GTPASES; DENDRITIC MORPHOGENESIS; ENDOCYTIC TRAFFICKING;

D O I：

10.1002/cm.21312

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Brain-derived neurotrophic factor (BDNF) and its receptors TrkB and p75 regulate dendritic and axonal growth during development and maintenance of the mature nervous system; however, the cellular and molecular mechanisms underlying this process are not fully understood. In recent years, several advances have shed new light on the processes behind the regulation of BDNF-mediated structural plasticity including control of neuronal transcription, local translation of proteins, and regulation of cytoskeleton and membrane dynamics. In this review, we summarize recent advances in the field of BDNF signaling in neurons to induce neuronal growth. (c) 2016 Wiley Periodicals, Inc.

引用

收藏

页码：612 / 628

页数：17

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