Perspective: virus infections and the death of neurons

被引：54

作者：

Griffin, DE ^{[1
]}

Hardwick, JM ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Hyg & Publ Hlth, Dept Mol Microbiol & Immunol, Baltimore, MD 21205 USA

来源：

TRENDS IN MICROBIOLOGY | 1999年 / 7卷 / 04期

关键词：

D O I：

10.1016/S0966-842X(99)01470-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Neuronotropic viruses induce apoptosis in neurons, and Bcl-2-related anti-apoptotic proteins and caspase inhibitors decrease mortality from acute viral encephalitis. Infected neurons develop cytoplasmic blebbing characteristic of apoptosis, but a paucity of apoptotic nuclear changes potentially indicates unique aspects of virus-induced neuronal apoptosis that remain to be discovered.

引用

页码：155 / 160

页数：6

共 44 条

[1] Virus infection induces neuronal apoptosis: A comparison with trophic factor withdrawal
Allsopp, TE
Scallan, MF
Williams, A
Fazakerley, JK
[J]. CELL DEATH AND DIFFERENTIATION, 1998, 5 (01) : 50 - 59
[2] Ariga T, 1998, J LIPID RES, V39, P1
[3] The p75 neurotrophin receptor mediates neuronal apoptosis and is essential for naturally occurring sympathetic neuron death
Bamji, SX
Majdan, M
Pozniak, CD
Belliveau, DJ
Aloyz, R
Kohn, J
Causing, CG
Miller, FD
[J]. JOURNAL OF CELL BIOLOGY, 1998, 140 (04) : 911 - 923
[4] Burek MJ, 1999, CELL DEATH AND DISEASES OF THE NERVOUS SYSTEM, P145
[5] Conversion of Bcl-2 to a Bax-like death effector by caspases
Cheng, EHY
Kirsch, DG
Clem, RJ
Ravi, R
Kastan, MB
Bedi, A
Ueno, K
Hardwick, JM
[J]. SCIENCE, 1997, 278 (5345) : 1966 - 1968
[6] Modulation of cell death by Bcl-xL through caspase interaction
Clem, RJ
Cheng, EHY
Karp, CL
Kirsch, DG
Ueno, K
Takahashi, A
Kastan, MB
Griffin, DE
Earnshaw, WC
Veliuona, MA
Hardwick, JM
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (02) : 554 - 559
[7] Despres P, 1998, J VIROL, V72, P823
[8] Interferon-gamma protects against herpes simplex virus type 1-mediated neuronal death
Geiger, KD
Nash, TC
Sawyer, S
Krahl, T
Patstone, G
Reed, JC
Krajewski, S
Dalton, D
Buchmeier, MJ
Sarvetnick, N
[J]. VIROLOGY, 1997, 238 (02) : 189 - 197
[9] CYTOKINE-MEDIATED SURVIVAL FROM LETHAL HERPES-SIMPLEX VIRUS-INFECTION - ROLE OF PROGRAMMED NEURONAL DEATH
GEIGER, KD
GURUSHANTHAIAH, D
HOWES, EL
LEWANDOWSKI, GA
REED, JC
BLOOM, FE
SARVETNICK, NE
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (08) : 3411 - 3415
[10] Death mechanisms in cultured cells infected by Semliki Forest virus
Glasgow, GM
McGee, MM
Sheahan, BJ
Atkins, GJ
[J]. JOURNAL OF GENERAL VIROLOGY, 1997, 78 : 1559 - 1563

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