Molybdenum and tungsten enzymes: the xanthine oxidase family

被引：82

作者：

Brondino, CD

Romao, MJ

Moura, I

Moura, JJG

机构：

[1] Univ Nacl Litoral, Fac Bioquim & Ciencias Biol, RA-3000 Santa Fe, Argentina

[2] Univ Nova Lisboa, Fac Ciencias & Tecnol, Dept Quim, REQUIMTE CQFB, P-2829516 Caparica, Portugal

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2006年 / 10卷 / 02期

关键词：

D O I：

10.1016/j.cbpa.2006.01.034

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mononuclear molybdenum and tungsten are found in the active site of a diverse group of enzymes that, in general, catalyze oxygen atom transfer reactions. Enzymes of the xanthine oxidase family are the best-characterized mononuclear Mo-containing enzymes. Several 3D structures of diverse members of this family are known. Recently, the structures of substrate-bound and arsenite-inhibited forms of two members of this family have also been reported. In addition, spectroscopic studies have been utilized to elucidate fine details that complement the structural information. Altogether, these studies have provided an important amount of information on the characteristics of the active site and the electron transfer pathways.

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页码：109 / 114

页数：6

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