Animal models for SARS and MERS coronaviruses

被引：127

作者：

Gretebeck, Lisa M. ^{[1
]}

Subbarao, Kanta ^{[1
]}

机构：

[1] NIAID, Natl Inst Hlth, Infect Dis Lab, Bethesda, MD 20892 USA

来源：

CURRENT OPINION IN VIROLOGY | 2015年 / 13卷

基金：

美国国家卫生研究院;

关键词：

ACUTE-RESPIRATORY-SYNDROME; GOLDEN-SYRIAN-HAMSTERS; ANGIOTENSIN-CONVERTING ENZYME-2; DIPEPTIDYL PEPTIDASE 4; MIDDLE-EAST; FUNCTIONAL RECEPTOR; BALB/C MICE; IMMUNE-RESPONSES; RHESUS MACAQUES; LUNG PATHOLOGY;

D O I：

10.1016/j.coviro.2015.06.009

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The emergence of Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) and Middle East Respiratory Syndrome coronavirus (MERS-CoV), two strains of animal coronaviruses that crossed the species barrier to infect and cause severe respiratory infections in humans within the last 12 years, have taught us that coronaviruses represent a global threat that does not recognize international borders. We can expect to see other novel coronaviruses emerge in the future. An ideal animal model should reflect the clinical signs, viral replication and pathology seen in humans. In this review, we present factors to consider in establishing an animal model for the study of novel coronaviruses and compare the different animal models that have been employed to study SARS-CoV and MERS-CoV.

引用

页码：123 / 129

页数：7

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