Role of Neisseria meningitides luxS in cell-to-cell signaling and bacteremic infection

被引：61

作者：

Winzer, K

Sun, YH

Green, A

Delory, M

Blackley, D

Hardie, KR

Baldwin, TJ

Tang, CM

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Ctr Mol Microbiol & Infect, Dept Infect Dis, London SW7 2AZ, England

[2] Queens Med Ctr, Inst Infect & Immun, Nottingham NG9 2EX, England

[3] John Radcliffe Hosp, Dept Paediat, Oxford OX3 9DU, England

来源：

INFECTION AND IMMUNITY | 2002年 / 70卷 / 04期

关键词：

D O I：

10.1128/IAI.70.4.2245-2248.2002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Numerous pathogenic bacteria contain luxS, which is required for autoinducer-2 production. Here, we demonstrate that Neisseria meningitides contains a functional copy of luxS that is necessary for full meningococcal virulence; strains with a luxS deletion are defective for bacteremia, a prerequisite of meningococcal pathogenesis.

引用

页码：2245 / 2248

页数：4

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