Dendrimeric Nanoarchitectures Mediated Transdermal and Oral Delivery of Bioactives

被引：26

作者：

Gajbhiye, V. ^{[1
]}

Kumar, P. Vijayaraj ^{[1
]}

Sharma, A. ^{[1
]}

Agarwal, A. ^{[1
]}

Asthana, A. ^{[1
]}

Jain, N. K. ^{[1
]}

机构：

[1] Dr Hari Singh Gour Vishwavidyalaya, Dept Pharmaceut Sci, Pharmaceut Res Lab, Sagar 470003, India

来源：

INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2008年 / 70卷 / 04期

关键词：

PAMAM dendrimer; transdermal; oral; transcellular; paracellular;

D O I：

10.4103/0250-474X.44589

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Transdermal route is an evolving panorama in novel drug deliverance and with oral route they proffer immense potential. Most recently there is hastening in approaches for delivering bioactives via these routes, amongst them revolution has been made by dendrimers. Encapsulation and conjugation of bioactives with these virus sized robots have shown immense employment for delivery of hydrophobic and labile remedies. Transport of these nano-cruises from corner to corner of skin and through epithelial hurdle of gastrointestinal tract depends upon dendrimer characteristics. An improved thoughtful of these characteristics is an obligation for their use in these rambling fields. These characteristics embrace generation size, molecular weight, surface charge, incubation time and concentration. This context demarcates the imperative role of dendrimers in transdermal and oral drug delivery. This review also highlights concerning mechanism of convey of nanoarrays via epithelial hurdle of GIT.

引用

页码：431 / 439

页数：9

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