Unveiling LOX-1 receptor interplay with nanotopography: mechanotransduction and atherosclerosis onset

被引：18

作者：

Di Rienzo, Carmine ^{[1
,2
,3
]}

Jacchetti, Emanuela ^{[1
,2
]}

Cardarelli, Francesco ^{[3
]}

Bizzarri, Ranieri ^{[1
,2
]}

Beltram, Fabio ^{[1
,2
]}

Cecchini, Marco ^{[1
,2
]}

机构：

[1] CNR, Ist Nanosci, NEST, I-56127 Pisa, Italy

[2] Scuola Normale Super Pisa, I-56127 Pisa, Italy

[3] Ist Italiano Tecnol, Nanotechnol Innovat NEST, I-56127 Pisa, Italy

来源：

SCIENTIFIC REPORTS | 2013年 / 3卷

关键词：

LOW-DENSITY-LIPOPROTEIN; OXIDIZED LDL RECEPTOR-1; LECTIN-LIKE; ENDOTHELIAL RECEPTOR; SHEAR-STRESS; GENE-EXPRESSION; POTENTIAL ROLE; IN-VIVO; ACTIVATION; MECHANISMS;

D O I：

10.1038/srep01141

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Lectin-like ox-LDL receptors (LOX-1) play a crucial role in the ox-LDL-induced pathological transformation of vessel-wall components, a crucial early step in atherogenesis. LOX-1 dynamics is quantitatively investigated in human endothelial cells (HUVECs) exposed to environmental nanotopographies. We demonstrate distinct nanotopography-induced cell phenotypes, characterized by different morphology, LOX-1 diffusivity and oligomerization state: HUVECs on flat surfaces exhibit the behavior found in pro-atherogenic conditions, while growth on nanogratings can interfere with LOX-1 dynamics and lead to a behavior characteristic of normal, non-pathological conditions.

引用

页数：8

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