Sleep-related O-2 desaturation and daytime pulmonary haemodynamics in COPD patients with mild hypoxaemia

被引:123
作者
Chaouat, A
Weitzenblum, E
Kessler, R
Charpentier, C
Ehrhart, M
LeviValensi, P
Zielinski, J
Delaunois, L
Cornudella, R
dosSantos, JM
机构
[1] UNIV HOSP,SERV PNEUMOL,STRASBOURG,FRANCE
[2] UNIV HOSP,SERV PNEUMOL,AMIENS,FRANCE
[3] INST TB & LUNG DIS,WARSAW,POLAND
[4] CLIN UNIV UCL,YVOIR,BELGIUM
[5] UNIV HOSP,BARCELONA,SPAIN
[6] SERV PNEUMOL,COIMBRA,PORTUGAL
关键词
chronic obstructive pulmonary disease; mild hypoxaemia; pulmonary hypertension; sleep-related hypoxaemia;
D O I
10.1183/09031936.97.10081730
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
It has been hypothesized but not firmly established that sleep-related hypoxaemia could favour the development of pulmonary hypertension in chronic obstructive pulmonary disease (COBB) patients without marked daytime hyperaemia, We have investigated the relationships between pulmonary function data, sleep-related desaturation and daytime pulmonary haemodynamics in a group of 94 COPD patients not qualifying for conventional O-2 therapy (daytime arterial oxygen tension (Pa,O-2) in the range 7.4-9.2 kPa (56-69 mmHg)), Nocturnal desaturation was defined by spending greater than or equal to 30% of the recording time with a transcutaneous O-2 Saturation <90%. An obstructive sleep apnoea syndrome was excluded by polysomnography, Sixty six patients were desaturators (Group 1) and 28 were nondesaturators (Group 2). There was no significant difference between Groups 1 and 2 with regard to pulmonary volumes and Pa,O-2 (8.4+/-0.6 vs 8.4+/-0.4 kPa (63+/-4; vs 63+/-3 mmHg)) but arterial carbon dioxide tension (Pa,CO2) was higher in Group 1 (6.0+/-0.7 vs 5.3+/-0.5 kPa (45+/-5 vs 40+/-4 mmHg); p<0,0001), Mean pulmonary artery pressure (<(P)over bar pa>) was very similar in the two groups (2.6+/-0.7 vs 2.5+/-0.6 kPa (19+/-5 vs 19+/-4 mmHg)). No individual variable or combination of variables could predict the presence of pulmonary hypertension. It is concluded that in these patients with chronic obstructive pulmonary disease with modest daytime hypoxaemia, functional and gasometric variables (with the noticeable exception of arterial carbon dioxide tension) cannot predict the presence of nocturnal desaturation; and that mean pulmonary artery pressure is not correlated with the degree and duration of nocturnal hypoxaemia. These results do not support the hypothesis that sleep-related hypoxaemia favours the development of pulmonary hypertension.
引用
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页码:1730 / 1735
页数:6
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