Thalidomide increases both REM and stage 3-4 sleep in human adults: A preliminary study

被引：19

作者：

Kanbayashi, T ^{[1
]}

Shimizu, T ^{[1
]}

Takahashi, Y ^{[1
]}

Kitajima, T ^{[1
]}

Takahashi, K ^{[1
]}

Saito, Y ^{[1
]}

Hishikawa, Y ^{[1
]}

机构：

[1] Akita Univ, Sch Med, Dept Neuropsychiat, Akita, Japan

来源：

SLEEP | 1999年 / 22卷 / 01期

关键词：

thalidomide; sleep; EEG; hypnotic; TNF alpha; immune system;

D O I：

10.1093/sleep/22.1.113

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Polysomnography was used to assess the effect of thalidomide on human sleep. This compound significantly increased the time spent in REM and stage 3-4 sleep as compared with placebo. On the other hand, thalidomide significantly decreased the time spent in stage 1, while the time spent in stage 2 was unchanged. The effect of thalidomide on REM and stage 3-4 sleep is unique as compared with other hypnotics. Although the mode of action of this compound is unknown, further studies on thalidomide should help in our understanding of the mechanisms of sleep regulation.

引用

页码：113 / 115

页数：3

共 11 条

[1] Thalidomide comes close to US approval [J].

Ault, A .

LANCET, 1997, 350 (9081) :873-873

[2] LENTIVIRAL INFECTION, IMMUNE-RESPONSE PEPTIDES AND SLEEP [J].

DARKO, DF ;

MITLER, MM ;

HENRIKSEN, SJ .

ADVANCES IN NEUROIMMUNOLOGY, 1995, 5 (01) :57-77

[3]

FREDERICKSON RCA, 1977, J PHARMACOL EXP THER, V203, P240

[4]

GUNZLER V, 1992, DRUG SAFETY, V7, P116

[5] EFFECTS OF THALIDOMIDE AND PENTOBARBITAL ON NEURONAL-ACTIVITY IN THE PREOPTIC AREA DURING SLEEP AND WAKEFULNESS IN THE CAT [J].

KAITIN, KI .

PSYCHOPHARMACOLOGY, 1985, 85 (01) :47-50

[6] Thalidomide, a hypnotic with immune modulating properties, increases cataplexy in canine narcolepsy [J].

Kanbayashi, T ;

Nishino, S ;

Tafti, M ;

Hishikawa, Y ;

Dement, WC ;

Mignot, E .

NEUROREPORT, 1996, 7 (12) :1881-1886

[7]

Kimura K, 1973, Nihon Yakurigaku Zasshi, V69, P599

[8]

Nishino Seiji, 1995, P405

[9]

Rechtschaffen A., 1968, BRAIN INFORM SERVICE

[10] Effects of thalidomide on HIV-associated wasting syndrome: A randomized, double-blind, placebo-controlled clinical trial [J].

ReyesTeran, G ;

SierraMadero, JG ;

delCerro, VM ;

ArroyoFigueroa, H ;

Pasquetti, A ;

Calva, JJ ;

RuizPalacios, GM .

AIDS, 1996, 10 (13) :1501-1507

← 1 2 →