Glaucomatous neurodegeneration: An eye on tumor necrosis factor-alpha

被引：41

作者：

Agarwal, Renu ^{[1
]}

Agarwal, Puneet ^{[1
]}

机构：

[1] Univ Teknol MARA, Dept Pharmacol, Fac Med, Shah Alam 40450, Selangor, Malaysia

来源：

INDIAN JOURNAL OF OPHTHALMOLOGY | 2012年 / 60卷 / 04期

关键词：

Apoptosis; glaucoma; intraocular pressure; retinal ganglion cells; retinal ischemia; tumor necrosis factor-alpha; NF-KAPPA-B; RETINAL GANGLION-CELLS; OPEN-ANGLE GLAUCOMA; TNF-ALPHA; NITRIC-OXIDE; AKT PHOSPHORYLATION; GENE POLYMORPHISM; AGMATINE PROTECTS; INDUCED APOPTOSIS; AQUEOUS-HUMOR;

D O I：

10.4103/0301-4738.98700

中图分类号：

R77 [眼科学];

学科分类号：

100212 [眼科学];

摘要：

Glaucoma, a neurodegenerative disease, is currently being treated by modulation of one of its primary risk factors, the elevated intraocular pressure. Newer therapies that can provide direct neuroprotection to retinal ganglion cells are being extensively investigated. Tumor necrosis factor-alpha, a cytokine, has been recognized to play an important role in pro and antiapoptotic cellular events. In this paper we review the relevant literature to understand (1) The association of increased expression of tumor necrosis factor-alpha with glaucomatous neurodegeneraion, (2) Modulation of tumor necrosis factor-alpha expression by exposure to various risk factors of glaucoma, (3) Downstream cellular signaling mechanisms following interaction of tumor necrosis factor-alpha with its receptors and (4) Role of tumor necrosis factor-alpha as a possible target for therapeutic intervention in glaucoma. Literature was reviewed using PubMed search engine with relevant key words and a total of 82 English language papers published from 1990 to 2010 are included in this review.

引用

页码：255 / 261

页数：7

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