HeLiVa platform: integrated heart-liver-vascular systems for drug testing in human health and disease

被引：59

作者：

Vunjak-Novakovic, Gordana ^{[1
]}

Bhatia, Sangeeta ^{[2
]}

Chen, Christopher ^{[3
,4
]}

Hirschi, Karen ^{[5
]}

机构：

[1] Columbia Univ, New York, NY 10032 USA

[2] MIT, Cambridge, MA 02139 USA

[3] Boston Univ, Boston, MA 02215 USA

[4] Harvard Univ, Wyss Inst Biol Inspired Engn, Boston, MA 02215 USA

[5] Yale Univ, New Haven, CT 06520 USA

来源：

STEM CELL RESEARCH & THERAPY | 2013年 / 4卷

基金：

美国国家卫生研究院;

关键词：

PLURIPOTENT STEM-CELLS; C VIRUS-INFECTION; IN-VITRO; TISSUE; DIFFERENTIATION; BIOREACTOR; NETWORKS; MATRIX;

D O I：

10.1186/scrt369

中图分类号：

Q813 [细胞工程];

学科分类号：

100113 [医学细胞生物学];

摘要：

Our project team is developing an integrated microphysiological platform with functionally connected vascular, liver and cardiac microtissues derived from a single line of human pluripotent stem cells. The platform enables functional representation of human physiology in conjunction with real-time biological readouts (via imaging and homologous reporters for all three cell phenotypes) and compatibility with high-throughput/high-content analysis. In this paper, we summarize progress made over the first year of the grant.

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页数：6

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