Does the serpin PI-9 protect tumor cells?

被引：12

作者：

Bots, Michael ^{[1
]}

Offringa, Rienk ^{[1
]}

Medema, Jan Paul ^{[1
]}

机构：

[1] Univ Amsterdam, Acad Med Ctr, LEXOR, NL-1105 AZ Amsterdam, Netherlands

来源：

BLOOD | 2006年 / 107卷 / 12期

关键词：

D O I：

10.1182/blood-2006-01-0291

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：4974 / 4975

页数：2

共 10 条

[1] Selective regulation of apoptosis: the cytotoxic lymphocyte serpin proteinase inhibitor 9 protects against granzyme B-mediated apoptosis without perturbing the Fas cell death pathway [J].

Bird, CH ;

Sutton, VR ;

Sun, JR ;

Hirst, CE ;

Novak, A ;

Kumar, S ;

Trapani, JA ;

Bird, PI .

MOLECULAR AND CELLULAR BIOLOGY, 1998, 18 (11) :6387-6398

[2] Serpins prevent granzyme-induced death in a species-specific manner [J].

Bots, M ;

Van Bostelen, L ;

Rademaker, MTGA ;

Offringa, R ;

Medema, JP .

IMMUNOLOGY AND CELL BIOLOGY, 2006, 84 (01) :79-86

[3] SPI-CI and SPI-6 cooperate in the protection from effector cell-mediated cytotoxicity [J].

Bots, M ;

Kolfschoten, IGM ;

Bres, SA ;

Rademaker, MTGA ;

de Roo, GM ;

Krüse, M ;

Franken, KLMC ;

Hahne, M ;

Froelich, CJ ;

Melief, CJM ;

Offringa, R ;

Medema, JP .

BLOOD, 2005, 105 (03) :1153-1161

[4]

Classen CF, 2004, HAEMATOLOGICA, V89, P1314

[5] Lymphomas are sensitive to perforin-dependent cytotoxic pathways despite expression of PI-9 and overexpression of bcl-2 [J].

Godal, R ;

Keilholz, U ;

Uharek, L ;

Letsch, A ;

Asemissen, AM ;

Busse, A ;

Na, IK ;

Thiel, E ;

Scheibenbogen, C .

BLOOD, 2006, 107 (08) :3205-3211

[6] Blockade of the granzyme B/perforin pathway through overexpression of the serine protease inhibitor PI-9/SPI-6 constitutes a mechanism for immune escape by tumors [J].

Medema, JP ;

de Jong, J ;

Peltenburg, LTC ;

Verdegaal, EME ;

Gorter, A ;

Bres, SA ;

Franken, KLMC ;

Hahne, M ;

Albar, JP ;

Melief, CJM ;

Offringa, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (20) :11515-11520

[7] The restricted expression of granzyme M in human lymphocytes [J].

Sayers, TJ ;

Brooks, AD ;

Ward, JM ;

Hoshino, T ;

Bere, WE ;

Wiegand, GW ;

Kelley, JM ;

Smyth, MJ .

JOURNAL OF IMMUNOLOGY, 2001, 166 (02) :765-771

[8]

Sutton VR, 1997, J IMMUNOL, V158, P5783

[9] Expression levels of apoptosis-related proteins predict clinical outcome in anaplastic large cell lymphoma [J].

ten Berge, RL ;

Meijer, CJLM ;

Dukers, DF ;

Kummer, JA ;

Bladergroen, BA ;

Vos, W ;

Hack, CE ;

Ossenkoppele, GJ ;

Oudejans, JJ .

BLOOD, 2002, 99 (12) :4540-4546

[10] Expression of the apoptosis inhibitor protease inhibitor 9 predicts clinical outcome in vaccinated patients with stage III and IV melanoma [J].

van Houdt, IS ;

Oudejans, JJ ;

van den Eertwegh, AJM ;

Baars, A ;

Vos, W ;

Bladergroen, BA ;

Rimoldi, D ;

Muris, JJFJIF ;

Hooijberg, E ;

Gundy, CM ;

Meijer, CLM ;

Kummer, JA .

CLINICAL CANCER RESEARCH, 2005, 11 (17) :6400-6407

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