Changes in the balance between Treg and Th17 cells in patients with chronic hepatitis B

被引：102

作者：

Su, Zhi-Jun ^{[1
]}

Yu, Xue-Ping ^{[1
]}

Guo, Ru-Yi ^{[1
]}

Ming, De-Song ^{[1
]}

Huang, Lv-Ye ^{[1
]}

Su, Mi-Long ^{[1
]}

Deng, Yong ^{[1
]}

Lin, Zhen-Zhong ^{[1
]}

机构：

[1] Fujian Med Univ, Hosp Quanzhou 1, Dept Infect Dis, Quanzhou 362000, Peoples R China

来源：

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2013年 / 76卷 / 04期

关键词：

Hepatitis B; Treg cells; Th17; cells; TGF-beta; 1; IL-17; IL-10; REGULATORY T-CELLS; LIVER-DISEASE; INFLAMMATION; INFECTION; PROGRESSION; ENTECAVIR; INTERPLAY; SEVERITY; LINEAGE; T(H)17;

D O I：

10.1016/j.diagmicrobio.2013.04.026

中图分类号：

R51 [传染病];

学科分类号：

100201 [内科学];

摘要：

The purpose of this study was to explore the role of Treg cells, Th17 cells and cytokines associated with Treg/Th17 differentiation in the occurrence, development and outcome of chronic hepatitis B (CHB). To do so, we detected populations of Treg and Th17 cells and their associated cytokines in the peripheral blood of CHB patients. The populations of Treg cells (CD4(+)CD25(high)CD127(low) T cells) and Th17 cells (CD3(+)CD8(-)IL-17(+) T cells) were analyzed in 46 patients with low to moderate chronic hepatitis B (CHB-LM), 24 patients with severe chronic hepatitis B (CHB-S) and 20 healthy controls (HC) using flow cytometry. The levels of cytokines associated with Treg/Th17 differentiation, including IL-10, TGF-beta 1, IL-17 and IL-23, were measured by enzyme-linked immunosorbent assay (ELISA). Our study showed that the imbalance of Treg and Th17 cells might play an important role in the occurrence, development and outcome of CHB. (c) 2013 Elsevier Inc. All rights reserved.

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收藏

页码：437 / 444

页数：8

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