Anti-tumor-promoting activity of the diterpene from Excoecaria agallocha.: II

被引：36

作者：

Konoshima, T ^{[1
]}

Konishi, T

Takasaki, M

Yamazoe, K

Tokuda, H

机构：

[1] Kyoto Pharmaceut Univ, Yamashina Ku, Kyoto 6078414, Japan

[2] Kyoto Prefectural Univ Med, Kamigyo Ku, Kyoto 6020841, Japan

来源：

BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2001年 / 24卷 / 12期

关键词：

anti-tumor-promoter; secolabdane-type diterpene; Excoecaria agallocha; two-stage carcinogenesis; Euphorbiaceae;

D O I：

10.1248/bpb.24.1440

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

Eight new diterpenoids (1-8) have been isolated from the wood of Excoecaria agallocha (Euphorbiaceae) and their inhibitory effects on the induction of Epstein-Barr virus early antigen (EBV-EA) in Raji cells were examined to search for potent anti-tumor-promoters from natural resources. Of these compounds, the secolabdane-type diterpenoid, compound 7 exhibited a remarkable inhibitory effect on EBV-EA induction, and a significant anti-tumor-promoting effect in the mouse two-stage carcinogenesis test using 7,12-dimethylbenz[a]anthracene and 12-O-tetradecanoyl-phorbol-13-acetate.

引用

页码：1440 / 1442

页数：3

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