Competitive bioreactor hens on the horizon

被引：30

作者：

Ivarie, R ^{[1
]}

机构：

[1] Univ Georgia, Dept Genet, Athens, GA 30602 USA

来源：

TRENDS IN BIOTECHNOLOGY | 2006年 / 24卷 / 03期

关键词：

D O I：

10.1016/j.tibtech.2006.01.004

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The hen has long held promise as a low-cost, high-yield bioreactor for the production of human biopharmaceuticals in egg whites using genetic engineering. Two separate reports have recently appeared indicating the production of substantial levels of human monoclonal and single chain antibodies (> 3mg and > 150mg, respectively) in eggs of transgenic hens. These promising findings indicate that the hen is close to becoming a competitive manufacturing platform for the production of human biopharmaceuticals.

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页码：99 / 101

页数：3

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