Heterologous expression systems for polyketide synthases

被引：42

作者：

Fujii, Isao ^{[1
]}

机构：

[1] Iwate Med Univ, Sch Pharm, Yahaba, Iwate 0283694, Japan

来源：

NATURAL PRODUCT REPORTS | 2009年 / 26卷 / 02期

关键词：

BIOSYNTHETIC GENE-CLUSTER; SITE-DIRECTED MUTAGENESIS; CHAIN-LENGTH CONTROL; ENGINEERED BIOSYNTHESIS; 16-MEMBERED MACROLIDES; ESCHERICHIA-COLI; STARTER UNIT; CLONING; PATHWAY; MACROLACTONE;

D O I：

10.1039/b817092b

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Polyketide synthases are the main biochemical machinery for the production of a structurally diverse group of natural products, polyketides. Their heterologous expression enables overproduction of target compounds, generation of novel analogs, and provides a basic understanding of their reaction programs. This Highlight outlines the current state of heterologous expression of type I, type II, and type III polyketide synthases of microbial and plant origins.

引用

页码：155 / 169

页数：15

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