New susceptibility locus for coronary artery disease on chromosome 3q22.3

被引：375

作者：

Erdmann, Jeanette ^{[1
]}

Grosshennig, Anika ^{[1
,2
]}

Braund, Peter S. ^{[3
]}

Koenig, Inke R. ^{[2
]}

Hengstenberg, Christian ^{[4
]}

Hall, Alistair S. ^{[5
]}

Linsel-Nitschke, Patrick ^{[1
]}

Kathiresan, Sekar ^{[6
,7
]}

Wright, Ben ^{[8
]}

Tregouet, David-Alexandre ^{[9
]}

Cambien, Francois ^{[9
]}

Bruse, Petra ^{[1
]}

Aherrahrou, Zouhair ^{[1
]}

Wagner, Arnika K. ^{[1
]}

Stark, Klaus ^{[4
]}

Schwartz, Stephen M. ^{[10
,11
]}

Salomaa, Veikko ^{[12
]}

Elosua, Roberto ^{[13
,14
]}

Melander, Olle ^{[15
]}

Voight, Benjamin F. ^{[16
]}

O'Donnell, Christopher J. ^{[17
]}

Peltonen, Leena ^{[18
]}

Siscovick, David S. ^{[10
,11
]}

Altshuler, David ^{[19
,20
]}

Merlini, Piera Angelica ^{[21
]}

Peyvandi, Flora ^{[22
]}

Bernardinelli, Luisa ^{[23
,24
]}

Ardissino, Diego ^{[25
]}

Schillert, Arne ^{[2
]}

Blankenberg, Stefan ^{[26
]}

Zeller, Tanja ^{[26
]}

Wild, Philipp ^{[26
]}

Schwarz, Daniel F. ^{[2
]}

Tiret, Laurence ^{[9
]}

Perret, Claire ^{[9
]}

Schreiber, Stefan ^{[27
]}

El Mokhtari, Nour Eddine ^{[27
]}

Schaefer, Arne ^{[27
]}

Maerz, Winfried ^{[28
,30
]}

Renner, Wilfried ^{[29
]}

Bugert, Peter ^{[31
,32
]}

Klueter, Harald ^{[31
,32
]}

Schrezenmeir, Juergen ^{[33
]}

Rubin, Diana ^{[33
]}

Ball, Stephen G. ^{[5
]}

Balmforth, Anthony J. ^{[5
]}

Wichmann, H-Erich ^{[34
,35
]}

Meitinger, Thomas ^{[36
,37
]}

Fischer, Marcus ^{[4
]}

Meisinger, Christa ^{[34
]}

机构：

[1] Med Univ Lubeck, Med Klin 2, D-23538 Lubeck, Germany

[2] Med Univ Lubeck, Inst Med Biometrie & Stat, D-23538 Lubeck, Germany

[3] Univ Leicester, Dept Cardiovasc Ctr, Glenfield Hosp, Leicester LE3 9QP, Leics, England

[4] Univ Regensburg, Klin & Poliklin Innere Med 2, D-93053 Regensburg, Germany

[5] Univ Leeds, LIGHT, Leeds LS1 3EX, W Yorkshire, England

[6] Harvard Univ, Sch Med, Cardiovasc Res Ctr, Boston, MA 02115 USA

[7] Harvard Univ, Sch Med, Ctr Human Genet Res, Massachusetts Gen Hosp, Boston, MA 02115 USA

[8] Univ Leicester, Dept Hlth Sci & Genet, Leicester LE1 7RH, Leics, England

[9] Univ Paris 06, INSERM, UMR S 525, Paris, France

[10] Univ Washington, Dept Epidemiol, Cardiovasc Hlth Res Unit, Seattle, WA 98109 USA

[11] Univ Washington, Dept Gen Med, Seattle, WA 98109 USA

[12] Natl Publ Hlth Inst, Dept Hlth Promot & Chron Dis Prevent, Chron Dis Epidemiol Unit, FI-00271 Helsinki, Finland

[13] Inst Municipal Invest Med, Cardiovasc Epidemiol & Genet Grp, Barcelona 08036, Spain

[14] Ciber Epidemiol & Salud Publ, CIBERESP, Barcelona, Spain

[15] Lund Univ, Malmo Univ Hosp, Dept Clin Sci Hypertens & Cardiovasc Dis, SE-20502 Malmo, Sweden

[16] Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA

[17] NHLBI, NIH, Bethesda, MD 20824 USA

[18] Wellcome Trust Sanger Inst, Cambridge CB10 1SA, England

[19] Harvard Univ, Sch Med, Dept Mol Biol, Boston, MA 02115 USA

[20] Harvard Univ, Sch Med, Ctr Human Genet Res, Massachusetts Gen Hosp, Boston, MA 02115 USA

[21] Azienda Osped Niguarda Ca Granda, Div Cardiol, I-20162 Milan, Italy

[22] Univ Milan, Osped Maggiore Mangiagalli & Regina Elena, Fdn Ist Ricovera & Cura Carattere Sci, Dept Internal Med & Med Special, I-20162 Milan, Italy

[23] Univ Pavia, Dept Appl Hlth Sci, I-27100 Pavia, Italy

[24] MRC, Biostat Unit, Cambridge CB2 0SR, England

[25] Univ Parma, Azienda Osped, Div Cardiol, I-43100 Parma, Italy

[26] Johannes Gutenberg Univ Mainz, Dept Med 2, D-55099 Mainz, Germany

[27] Univ Kiel, Inst Klin Mol Biol, D-24118 Kiel, Germany

[28] Synlab Ctr Lab Diagnost Heidelberg, D-69037 Heidelberg, Germany

[29] Med Univ Graz, Clin Inst Med & Chem Lab Diagnost, A-8036 Graz, Austria

[30] Univ Heidelberg, Dept Publ Hlth Social & Prevent Med, D-69117 Heidelberg, Germany

[31] Univ Heidelberg, Inst Transfus Med & Immunol, D-69117 Heidelberg, Germany

[32] Med Fac Mannheim, D-68131 Mannheim, Germany

[33] Inst Physiol & Biochem Ernahrung, Bundesforsch Sanstalt Ernahrung & Lebensmittel, D-24118 Kiel, Germany

[34] German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Epidemiol, D-85764 Neuherberg, Germany

[35] LMU, Inst Med Informat Sci Biometry & Epidemiol, D-80539 Munich, Germany

[36] Deutsch Forschungszentrum Umwelt & Gesundheit, Helmholtz Zentrum Munchen, Inst Humangenet, D-85764 Neuherberg, Germany

[37] Tech Univ Munich, Inst Humangenet, D-80333 Munich, Germany

[38] Univ Cambridge, Dept Haematol, Cambridge CB2 2PT, England

来源：

NATURE GENETICS | 2009年 / 41卷 / 03期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

ASSOCIATION; GENOME;

D O I：

10.1038/ng.307

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We present a three-stage analysis of genome-wide SNP data in 1,222 German individuals with myocardial infarction and 1,298 controls, in silico replication in three additional genome-wide datasets of coronary artery disease (CAD) and subsequent replication in similar to 25,000 subjects. We identified one new CAD risk locus on 3q22.3 in MRAS (P = 7.44 x 10(-13); OR = 1.15, 95% CI = 1.11-1.19), and suggestive association with a locus on 12q24.31 near HNF1A-C12orf43 (P = 4.81 x 10(-7); OR = 1.08, 95% CI = 1.05-1.11).

引用

页码：280 / 282

页数：3

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