Clinical implication of ZEB-1 and E-cadherin expression in hepatocellular carcinoma (HCC)

被引：97

作者：

Hashiguchi, Motoyuki ^{[1
]}

Ueno, Shinichi ^{[1
,2
]}

Sakoda, Masahiko ^{[1
]}

Iino, Satoshi ^{[1
]}

Hiwatashi, Kiyokazu ^{[1
]}

Minami, Koji ^{[1
]}

Ando, Kei ^{[1
]}

Mataki, Yuko ^{[1
]}

Maemura, Kosei ^{[1
]}

Shinchi, Hiroyuki ^{[1
]}

Ishigami, Sumiya ^{[1
]}

Natsugoe, Shoji ^{[1
]}

机构：

[1] Kagoshima Univ, Dept Digest Surg Breast & Thyroid Surg, Grad Sch Med & Dent Sci, Kagoshima 890, Japan

[2] Kagoshima Univ, Dept Clin Oncol, Course Adv Therapeut, Grad Sch Med & Dent Sci, Kagoshima 890, Japan

来源：

BMC CANCER | 2013年 / 13卷

关键词：

Hepatocellular carcinoma; Hepatic resection; ZEB-1; E-cadherin; EMT; EPITHELIAL-MESENCHYMAL TRANSITION; CURRENT-MANAGEMENT; PANCREATIC-CANCER; BETA-CATENIN; METASTASIS; REPRESSOR; RESECTION; SURVIVAL; DISEASE; PROTEIN;

D O I：

10.1186/1471-2407-13-572

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Background: While recent research has shown that expression of ZEB-1 in a variety of tumors has a crucial impact on patient survival, there is little information regarding ZEB-1 expression in hepatocellular carcinoma (HCC). This study investigated the co-expression of ZEB-1 and E-cadherin in HCC by immunohistochemistry and evaluated its association with clinical factors, including patient prognosis. Methods: A total of 108 patients with primary HCC treated by curative hepatectomy were enrolled. ZEB-1 expression was immunohistochemically categorized as positive if at least 1% cancer cells exhibited nuclear staining. E-cadherin expression was divided into preserved and reduced expression groups and correlations between ZEB-1 and E-cadherin expression and clinical factors were then evaluated. Results: With respect to ZEB-1 expression, 23 patients were classified into the positive group and 85 into the negative group. Reduced E-cadherin expression was seen in 44 patients and preserved expression in the remaining 64 patients. ZEB-1 positivity was significantly associated with reduced expression of E-cadherin (p = 0.027). Moreover, significant associations were found between ZEB-1 expression and venous invasion and TNM stage. ZEB-1 positivity was associated with poorer prognosis (p = 0.025). Reduced E-cadherin expression was significantly associated with intrahepatic metastasis and poorer prognosis (p = 0.047). In particular, patients with both ZEB-1 positivity and reduced E-cadherin expression had a poorer prognosis (p = 0.005). Regardless of E-cadherin status, ZEB-1 was not a significant prognostic factor by multivariate analysis. There was no statistical difference in overall survival when E-cadherin expression was reduced in the ZEB-1 positive group (p = 0.24). Conclusions: Positive ZEB-1 expression and loss of E-cadherin expression are correlated with poor prognosis in HCC patients and malignancy of ZEB-1 positive tumors involves EMT.

引用

页数：8

共 30 条

[1]

Current concepts in hepatic resection for hepatocellular carcinoma in cirrhotic patients [J].