Neurotrophins and their involvement in digestive cancers

被引：64

作者：

Blondy, Sabrina ^{[1
]}

Christou, Niki ^{[1
,2
]}

David, Valentin ^{[1
,3
]}

Verdier, Mireille ^{[1
]}

Jauberteau, Marie-Odile ^{[1
,4
]}

Mathonnet, Muriel ^{[1
,2
]}

Perraud, Aurelie ^{[1
,2
]}

机构：

[1] Univ Limoges, Controle Activat Cellulaire Progress Tumorale & R, Lab EA3842 CAPTuR, Fac Med, 2 Rue Docteur Marcland, F-87025 Limoges, France

[2] CHU Limoges, Serv Chirurg Digest Endocrinienne & Gen, 2 Ave Martin Luther King, F-87042 Limoges, France

[3] CHU Limoges, Serv Pharm, 2 Ave Martin Luther King, F-87042 Limoges, France

[4] CHU Limoges, Serv Immunol, 2 Ave Martin Luther King, F-87042 Limoges, France

来源：

CELL DEATH & DISEASE | 2019年 / 10卷 / 2期

关键词：

NERVE GROWTH-FACTOR; HEPATOCELLULAR-CARCINOMA CELLS; TROPOMYOSIN-RELATED KINASE; PERINEURAL INVASION; GASTRIC-CANCER; RECEPTOR; PROLIFERATION; EXPRESSION; OVEREXPRESSION; TRKB;

D O I：

10.1038/s41419-019-1385-8

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Cancers of the digestive system, including esophageal, gastric, pancreatic, hepatic, and colorectal cancers, have a high incidence and mortality worldwide. Efficient therapies have improved patient care; however, many challenges remain including late diagnosis, disease recurrence, and resistance to therapies. Mechanisms responsible for these aforementioned challenges are numerous. This review focuses on neurotrophins, including NGF, BDNF, and NT3, and their specific tyrosine kinase receptors called tropomyosin receptor kinase (Trk A, B, C, respectively), associated with sortilin and the p75 neurotrophin receptor (p75NTR), and their implication in digestive cancers. Globally, p75NTR is a frequently downregulated tumor suppressor. On the contrary, Trk and their ligands are considered oncogenic factors. New therapies which target NT and/or their receptors, or use them as diagnosis biomarkers could help us to combat digestive cancers.

引用

页数：12

共 79 条

[1]