Decreased Ebola Transmission after Rapid Response to Outbreaks in Remote Areas, Liberia, 2014

被引：28

作者：

Lindblade, Kim A. ^{[1
]}

Kateh, Francis ^{[2
]}

Nagbe, Thomas K. ^{[2
]}

Neatherlin, John C. ^{[1
]}

Pillai, Satish K. ^{[1
]}

Attfield, Kathleen R. ^{[1
]}

Dweh, Emmanuel ^{[2
]}

Barradas, Danielle T. ^{[1
]}

Williams, Seymour G. ^{[1
]}

Blackley, David J. ^{[1
]}

Kirking, Hannah L. ^{[1
]}

Patel, Monita R. ^{[1
]}

Dea, Monica ^{[1
]}

Massoudi, Mehran S. ^{[1
]}

Wannemuehler, Kathleen ^{[1
]}

Barskey, Albert E. ^{[1
]}

Zarecki, Shauna L. Mettee ^{[1
]}

Fomba, Moses ^{[2
]}

Grube, Steven ^{[1
]}

Belcher, Lisa ^{[1
]}

Broyles, Laura N. ^{[1
]}

Maxwell, T. Nikki ^{[1
]}

Hagan, Jose E. ^{[1
]}

Yeoman, Kristin ^{[1
]}

Westercamp, Matthew ^{[1
]}

Forrester, Joseph ^{[1
]}

Mott, Joshua ^{[1
]}

Mahoney, Frank ^{[1
]}

Slutsker, Laurence ^{[1
]}

DeCock, Kevin M. ^{[1
]}

Nyenswah, Tolbert ^{[2
]}

机构：

[1] Ctr Dis Control & Prevent, Atlanta, GA USA

[2] Minist Hlth & Social Welf, Monrovia, CA, Liberia

来源：

EMERGING INFECTIOUS DISEASES | 2015年 / 21卷 / 10期

关键词：

HEMORRHAGIC-FEVER; VIRUS DISEASE; CONGO; RISK;

D O I：

10.3201/eid2110.150912

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We measured the reproduction number before and after interventions were implemented to reduce Ebola transmission in 9 outbreaks in Liberia during 2014. We evaluated risk factors for secondary cases and the association between patient admission to an Ebola treatment unit (ETU) and survival. The reproduction number declined 94% from 1.7 (95% Cl 1.1-2.6) to 0.1 (95% Cl 0.02-0.6) after interventions began. The risk for secondary infections was 90% lower for patients admitted to an ETU (risk ratio 0.1, 95% Cl 0.04-0.3) than for those who died in the community. The case-fatality rate was 68% (95% Cl 60-74), and ETU admission was associated with a 50% reduction in death (hazard ratio 0.5, 95% Cl 0.4-0.8). Isolation and treatment of Ebola patients had the dual benefit of interrupting community transmission and improving survival.

引用

页码：1800 / 1807

页数：8

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