The genetic structure of a province as revealed by surnames and HLA genes: Potential utility in transplantation policy

被引：6

作者：

Guglielmino, CR ^{[1
]}

deSilvestri, A ^{[1
]}

Martinetti, M ^{[1
]}

Daielli, C ^{[1
]}

Salvaneschi, L ^{[1
]}

Cuccia, M ^{[1
]}

机构：

[1] POLICLIN SAN MATTEO,IRCCS,SERV IMMUNOEMATOL & TRASFUS,I-27100 PAVIA,ITALY

来源：

ANNALS OF HUMAN GENETICS | 1996年 / 60卷

关键词：

D O I：

10.1111/j.1469-1809.1996.tb00425.x

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The combined use of surnames, which simulate selectively neutral genetic markers, and HLA genes may constitute a useful tool for the genetic survey of a small area. We found a coincidence between HLA genetic structure and surname 'selectively neutral' pattern, in an Italian province, although HLA genes indicate a more pronounced genetic isolation for one particular subregion of the province. The patchiness of HLA allele distribution that is sometimes created by drift and/or selection can be used as the basis both of anthropological and of epidemiological studies. The creation of genetic maps of relatively small areas may also constitute a tool for the selection of bone marrow donors.

引用

页码：221 / 229

页数：9

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