Zone-dependent mechanical properties of human articular cartilage obtained by indentation measurements

被引：116

作者：

Antons, J. ^{[1
]}

Marascio, M. G. M. ^{[2
]}

Nohava, J. ^{[3
]}

Martin, R. ^{[4
]}

Applegate, L. A. ^{[5
]}

Bourban, P. E. ^{[2
]}

Pioletti, D. P. ^{[1
]}

机构：

[1] Ecole Polytech Fed Lausanne, Inst Bioengn, Lab Biomech Orthoped, Lausanne, Switzerland

[2] Ecole Polytech Fed Lausanne, Inst Mat Sci, Lab Proc Adv Composites, Lausanne, Switzerland

[3] Anton Paar, Peseux, Switzerland

[4] Lausanne Univ Hosp CHUV, Dept Musculoskeletal Med, Lausanne, Switzerland

[5] Lausanne Univ Hosp CHUV, Regenerat Therapy Unit, Lausanne, Switzerland

来源：

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE | 2018年 / 29卷 / 05期

基金：

瑞士国家科学基金会;

关键词：

ATOMIC-FORCE MICROSCOPY; NANOINDENTATION; DEGENERATION; INTERFACE; REPAIR; BONE;

D O I：

10.1007/s10856-018-6066-0

中图分类号：

R318 [生物医学工程];

学科分类号：

100103 [病原生物学];

摘要：

Emerging 3D printing technology permits innovative approaches to manufacture cartilage scaffolds associated with layer-by-layer mechanical property adaptation. However, information about gradients of mechanical properties in human articular cartilage is limited. In this study, we quantified a zone-dependent change of local elastic modulus of human femoral condyle cartilage by using an instrumented indentation technique. From the cartilage superficial zone towards the calcified layer, a gradient of elastic modulus values between 0.020 +/- 0.003 MPa and 6.44 +/- 1.02MPa was measured. To validate the tissue quality, the histological tissue composition was visualized by glycosaminoglycan and collagen staining. This work aims to introduce a new protocol to investigate the zone-dependent mechanical properties of graded structures, such as human articular cartilage. From this knowledge, better cartilage repair strategies could be tailored in the future.

引用

页数：8

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