Motor Circuits in Action: Specification, Connectivity, and Function

被引：240

作者：

Arber, Silvia ^{[1
,2
]}

机构：

[1] Univ Basel, Biozentrum, Dept Cell Biol, CH-4056 Basel, Switzerland

[2] Friedrich Miescher Inst Biomed Res, CH-4058 Basel, Switzerland

来源：

NEURON | 2012年 / 74卷 / 06期

基金：

瑞士国家科学基金会;

关键词：

DEVELOPING CEREBRAL-CORTEX; ZEBRAFISH SPINAL-CORD; ETS GENE PEA3; LOCOMOTOR-ACTIVITY; REGULATORY NETWORK; TRANSCRIPTIONAL CODES; SPINOCEREBELLAR TRACT; EXTENSOR MOTONEURONS; NEURONAL DIVERSITY; HINDLIMB MUSCLES;

D O I：

10.1016/j.neuron.2012.05.011

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Mammalian motor behavior is enabled by a hierarchy of interleaved circuit modules constructed by interneurons in the spinal cord, sensory feedback loops, and bilateral communication with supraspinal centers. Neuronal subpopulations are specified through a process of precisely timed neurogenesis, acquisition of transcriptional programs, and migration to spatially confined domains. Developmental and genetic programs instruct stereotyped and highly specific connectivity patterns, binding functionally distinct neuronal subpopulations into motor circuit modules at all hierarchical levels. Recent work demonstrates that spatial organization of motor circuits relates to precise connectivity patterns and that these patterns frequently correlate with specific behavioral functions of motor output. This Review highlights key examples of how developmental specification dictates organization of motor circuit connectivity and thereby controls movement.

引用

页码：975 / 989

页数：15

共 115 条

[1]

Snapshot: Spinal Cord Development [J].