Scintigraphic assessment of salivary function after intensity-modulated radiotherapy for head and neck cancer: Correlations with parotid dose and quality of life

被引：33

作者：

Chen, Wen-Cheng ^{[1
]}

Lai, Chia-Hsuan ^{[1
]}

Lee, Tsair-Fwu ^{[2
]}

Hung, Chao-Hsiung ^{[1
]}

Liu, Kuo-Chi ^{[1
]}

Tsai, Ming-Fong ^{[3
]}

Wang, Wen-Hung ^{[4
]}

Chen, Hungcheng ^{[5
]}

Fang, Fu-Ming ^{[6
]}

Chen, Miao-Fen ^{[1
,7
]}

机构：

[1] Chang Gung Mem Hosp, Dept Radiat Oncol, Chiayi, Hsien, Taiwan

[2] Natl Kaohsiung Univ Appl Sci, Dept Elect Engn, Med Phys & Informat Lab, Kaohsiung 807, Taiwan

[3] Chang Gung Mem Hosp, Dept Nucl Med, Chiayi, Hsien, Taiwan

[4] Chang Gung Mem Hosp, Dept Otolaryngol Head & Neck Surg, Chiayi, Hsien, Taiwan

[5] Helen F Graham Canc Ctr, Dept Radiat Oncol, Newark, DE USA

[6] Chang Gung Mem Hosp, Dept Radiat Oncol, Kaohsiung, Taiwan

[7] Chang Gung Univ, Coll Med, Grad Inst Clin Med, Tao Yuan, Taiwan

来源：

ORAL ONCOLOGY | 2013年 / 49卷 / 01期

关键词：

Head and neck cancer; Xerostomia; Parotid gland function; Intensity-modulated radiotherapy; Quality of life; STAGE NASOPHARYNGEAL CARCINOMA; GLAND FUNCTION; CONVENTIONAL RADIOTHERAPY; INITIAL REPORT; VOLUME; XEROSTOMIA; IRRADIATION;

D O I：

10.1016/j.oraloncology.2012.07.004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Objective: We investigated salivary function using quantitative scintigraphy and sought to identify functional correlations between parotid dose and quality of life (QoL) for head and neck cancer (HNC) patients receiving intensity-modulated radiotherapy (IMRT). Materials and methods: Between August, 2007 and June, 2008, 31 patients treated IMRT for HNC were enrolled in this prospective study. Salivary excretion function (SEF) was previously measured by salivary scintigraphy at annual intervals for 2 years after IMRT. A dose-volume histogram of each parotid gland was calculated, and the normal tissue complication probability (NTCP) was used to determine the tolerance dose. QoL was longitudinally assessed by the EORTC QLQ-C30 and H&N35 questionnaires prior to RT, and at one, three, 12 and 24 months after RT. Results: A significant correlation was found between the reduction of SEF and the mean parotid dose measured at 1 year (correlation coefficient, R-2 = 0.651) and 2 years (R-2 = 0.310) after IMRT (p < 0.001). The TD50 of the parotid gland at 1 year after IMRT is 43.6 Gy, comparable to results from western countries. We further found that contralateral parotid and submandibular gland function preservation was correlated with reduced sticky saliva and a better QoL compared to the functional preservation of both parotid glands, as determined by the EORTC QLQ-H&N35 questionnaire. Conclusion: A significant correlation was found between the reduction of SEF and the mean parotid dose. Preservation of contralateral parotid and submandibular gland function predicts a better QoL compared to preservation of the function of both parotid glands. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：42 / 48

页数：7

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