Immediate and late effects of coronary angiography on soluble endothelial cell markers and P-selectin in patients with and without coronary artery disease

被引:13
作者
Warzok, F
Steiner, M
Blann, AD
Weber, F
Urbaszek, W
Schuff-Werner, P
机构
[1] Univ Rostock, Fac Med, Dept Cardiol, D-18057 Rostock, Germany
[2] Inst Clin Chem & Pathobiochem, Rostock, Germany
[3] Univ Birmingham, City Hosp, Dept Med, Haemostasis Thrombosis & Vasc Biol Unit, Birmingham, W Midlands, England
关键词
P-selectin; von Willebrand factor; thrombomodulin; coronary artery disease; angiography;
D O I
10.1097/00001721-199909000-00009
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Endothelial cell injury and platelet activation are considered primary events in the pathogenesis of coronary artery disease (CAD) and are marked by plasma concentrations of von Willebrand factor (vWF) and soluble thrombomodulin, and by soluble P-selectin, respectively. Because both endothelial cells and platelets interact with contrast media, we aimed to detect immediate and 24-h changes in these markers following coronary angiography in patients with and without CAD. Sixteen patients with angiographically proven CAD and 14 patients without significant coronary stenosis were investigated. Blood samples were obtained from an antecubital vein before and 24 h after cardiac catheterization, and from the coronary sinus before and immediately after angiography. Concentrations of the markers were determined using enzyme-linked immunosorbent assays. In the coronary sinus samples, the only significant finding was an increase in levels of soluble P-selectin in the patients with CAD (P < 0.038). In the post-catheterization peripheral blood samples, concentrations of soluble P-selectin (P = 0.004), vWF (P = 0.0007) and soluble thrombomodulin (P = 0.0013) were all increased in patients with CAD. In contrast, patients without CAD demonstrated increased levels of vWF only (P = 0.0015) in peripheral blood samples obtained 24 h after angiography. We conclude that both immediate and 24-h changes take place in endothelial cells and platelet markers in response to cardiac catheterization, and that these changes are different in patients with angiographically proven CAD and in patients free of disease. These differences may reflect alterations in endothelial cell or platelet reactivity in patients with CAD. Blood Coag Fibrinol 10:381-387 (C) 1999 Lippincott Williams & Wilkins.
引用
收藏
页码:381 / 387
页数:7
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