A pilot MRI study of organ specific hemosiderosis and functional correlation in Chinese patients with myelodysplasia and aplastic anemia with raised ferritin levels

被引：11

作者：

Au, W. Y. ^{[1
]}

Lam, W. W. M. ^{[6
]}

Chu, W. W. C. ^{[6
]}

Tam, S. ^{[2
]}

Wong, W. K. ^{[2
]}

Chan, H. ^{[3
]}

Law, M. F. ^{[4
]}

Liu, H. S. Y. ^{[5
]}

Liang, R. ^{[1
]}

机构：

[1] Queen Mary Hosp, Dept Med, Hong Kong, Hong Kong, Peoples R China

[2] Queen Mary Hosp, Clin Biochem Unit, Hong Kong, Hong Kong, Peoples R China

[3] Queen Elizabeth Hosp, Dept Med, Hong Kong, Hong Kong, Peoples R China

[4] Tuen Mun Hosp, Dept Med, Hong Kong, Hong Kong, Peoples R China

[5] Pamela Youde Nethersole Hosp, Dept Med, Hong Kong, Hong Kong, Peoples R China

[6] Prince Wales Hosp, Dept Radiol, Hong Kong, Hong Kong, Peoples R China

来源：

HEMATOLOGICAL ONCOLOGY | 2008年 / 26卷 / 04期

关键词：

myelodysplasia; aplastic anemia; hemosiderosis;

D O I：

10.1002/hon.862

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

We performed MRI and endocrine assessment in 27 adult Chinese patients with severe aplastic anemia (SAA) and myelodysplasia (MDS). Despite high ferritin levels, cardiac hemosiderosis and heart failure was not common, and were not concordant in most cases. However, significant correlation was found between cardiac T2/T2* MRI assessment, ejection fraction and ferritin levels. Furthermore, there was a high incidence subclinical pancreatic abnormality that was related to liver MRI T2* readings. Hence, chelating agents may still have a role to improve organ function. Prospective data with serial functional and imaging monitoring is needed. Copyright (C) 2008 John Wiley & Sons, Ltd.

引用

页码：225 / 228

页数：4

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