Ion transport in sperm signaling

被引：156

作者：

Darszon, A ^{[1
]}

Beltrán, C

Felix, R

Nishigaki, T

Treviño, CL

机构：

[1] Univ Nacl Autonoma Mexico, Inst Biotecnol, Dept Genet & Fisiol Mol, Cuernavaca 62250, Morelos, Mexico

[2] IPN, CINVESTAV, Dept Fisiol Biofis & Neurociencias, Mexico City 07738, DF, Mexico

来源：

DEVELOPMENTAL BIOLOGY | 2001年 / 240卷 / 01期

关键词：

acrosome reaction; capacitation; fertilization; ion channels; ion transport; sperm; spermatogenic cells;

D O I：

10.1006/dbio.2001.0387

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Ion channels and transporters, key elements in sperm-egg signaling and environmental sensing, are essential for fertilization. External cues and components from the outer envelopes of the egg influence sperm ion permeability and behavior. Combining in vivo measurements of membrane potential, intracellular ions, and second messengers with new molecular approaches and reconstitution strategies are revealing how sperm ion channels participate in motility, sperm maturation, and the acrosome reaction. Sperm are tiny differentiated terminal cells unable to synthesize proteins and difficult to characterize electrophysiologically. Spermatogenic cells, the progenitors of sperm, have become useful tools for probing sperm ion channels since they are larger and molecular biology techniques can be applied. These complementary strategies are opening new avenues to determine how sperm ion channels function in gamete signaling. (C) 2001 Academic Press.

引用

页码：1 / 14

页数：14

共 183 条

[1] Sulfated polysaccharides from the egg jelly layer are species-specific inducers of acrosomal reaction in sperms of sea urchins [J].