Cytokines in Human Milk: Properties and Potential Effects upon the Mammary Gland and the Neonate

被引：91

作者：

Goldman, Armond S. ^{[1
]}

Chheda, Sadhana ^{[1
]}

Garofalo, Roberto ^{[1
]}

Schmalstieg, Frank C. ^{[1
]}

机构：

[1] Univ Texas Med Branch, Dept Pediat, Galveston, TX 77555 USA

来源：

JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA | 1996年 / 1卷 / 03期

关键词：

Human milk; mammary gland; cytokines; immunology; infancy;

D O I：

10.1007/BF02018078

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Epidemiologic and immunologic studies of breastfed and nonbreastfed infants and investigations of certain biologic activities in human milk led to the identification of immunomodulating agents in human milk. Among them were the cytokines interleukin-1 beta (IL-1 beta)(3); IL-6, lL-8, IL-10, granulocyte-colony stimulating factor, macrophage-colony stimulating factor (M-CSF), tumor necrosis factor-alpha, interferon-gamma, epithelial growth factor (EGF), transforming growth factor-alpha (TGF-alpha), and TGF-beta 2. Interferon-gamma may originate from T cells in milk; EGF, TGF-alpha, TGF-beta, M-CSF, IL-6, and IL-8 may be produced by mammary gland epithelium. Based upon their known functions, we hypothesize that cytokines influence the development and immunologic function of the mammary gland and the neonate. Those in vivo functions remain to be defined by future investigations.

引用

页码：251 / 258

页数：8

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