Real-time and background-free detection of nanoscale particles

被引：101

作者：

Ignatovich, FV ^{[1
]}

Novotny, L ^{[1
]}

机构：

[1] Univ Rochester, Inst Opt, Rochester, NY 14627 USA

来源：

PHYSICAL REVIEW LETTERS | 2006年 / 96卷 / 01期

关键词：

D O I：

10.1103/PhysRevLett.96.013901

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

We introduce a background-free real-time detection scheme capable of recognizing low-index nanoparticles such as single viruses in water. The method is based on interferometrically measuring the electromagnetic field amplitude of the scattered light. A split detector is used to generate a background-free signal that renders unprecedented sensitivity for small particles. In its current configuration the sensor is capable of detecting low-index particles in water down to 10 nm in radius or single gold particles as small as 5 nm. We demonstrate the detection of such small particles in a microfluidic system with a time resolution of 1 ms and we discuss the theoretical limits of this novel detection scheme.

引用

页数：4

共 23 条

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[2]

Batchelder J.S., 1991, U.S. Patent, Patent No. [5,061,070, 5061070]

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