Comparison of two commercially available gamma interferon blood tests for immunodiagnosis of tuberculosis

被引:105
作者
Dominguez, Jose [1 ,3 ,4 ]
Ruiz-Manzano, Juan [2 ,3 ,4 ]
De Souza-Galvao, Malu [3 ,5 ]
Latorre, Irene [1 ,3 ,4 ]
Mila, Celia [5 ]
Blanco, Silvia [1 ,3 ,4 ]
Angeles Jimenez, M. [5 ]
Prat, Cristina [1 ,3 ,4 ]
Lacoma, Alicia [1 ,3 ]
Altet, Neus [5 ]
Ausina, Vicente [1 ,3 ,4 ]
机构
[1] Hosp Univ Germans Trias & Pujol, Fdn Inst Ciencies Salut Germans Trias & Pujol, Microbiol Serv, Barcelona 08916, Spain
[2] Hosp Univ Germans Trias & Pujol, Fdn Inst Ciencies Salut Germans Trias & Pujol, Serv Pneumol, Barcelona 08916, Spain
[3] Univ Autonoma Barcelona, Bellaterra, Spain
[4] Inst Salud Carlos III, Badalona, Spain
[5] Unidad Prevenc & Control TB Barcelona, Barcelona, Spain
关键词
D O I
10.1128/CVI.00364-07
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
We evaluated the T-SPOT. TB and Quantiferon-TB Gold In tube (QFN-G-IT) tests for diagnosing Mycobacterium tuberculosis infection. T-SPOT. TB was more sensitive than QFN-G-IT in diagnosing both active and latent infection. Both gamma interferon tests were unaffected by prior Mycobacterium bovis BCG vaccination. Among children who were not BCG vaccinated but had a positive tuberculin skin test, QFN-G-IT was negative in 53.3% of cases, and T-SPOT. TB was negative in 50% of cases.
引用
收藏
页码:168 / 171
页数:4
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