Aging, stem cells, and mammalian target of rapamycin: A prospect of pharmacologic rejuvenation of aging stem cells

被引：66

作者：

Blagosklonny, Mikhail V. ^{[1
,2
]}

机构：

[1] Ordway Res Inst, Ctr Canc, Albany, NY 12208 USA

[2] Oncotarget, Albany, NY USA

来源：

REJUVENATION RESEARCH | 2008年 / 11卷 / 04期

关键词：

D O I：

10.1089/rej.2008.0722

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 [法学]; 0303 [社会学]; 100203 [老年医学];

摘要：

What is the relationship between stem cell aging and organismal aging? Does stem cell aging cause organismal aging or vice versa? Will stem cell aging aggravate age-related diseases? And what is stem cell aging? As suggested herein, hyperstimulation of signal transduction pathways can render cells compensatorily irresponsive. And the hallmark of stem cell aging is poor responsiveness to activating stimuli. On the basis of the hypothesis that insensitivity to stimuli is in part due to hyperactivation of the target of rapamycin (TOR), this article suggests a means of pharmacologic rejuvenation of stem cells and wound-healing cells.

引用

页码：801 / 808

页数：8

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