Tools for mapping high-throughput sequencing data

被引:161
作者
Fonseca, Nuno A. [1 ]
Rung, Johan [1 ]
Brazma, Alvis [1 ]
Marioni, John C. [1 ]
机构
[1] European Bioinformat Inst, EMBL Outstn, Cambridge CB10 ISD, England
关键词
RNA-SEQ DATA; SPLICE JUNCTIONS; RAPID ALIGNMENT; READ ALIGNMENT; GENOME; GENERATION; OLIGONUCLEOTIDES; ALGORITHM; ULTRAFAST; SOFTWARE;
D O I
10.1093/bioinformatics/bts605
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Motivation: A ubiquitous and fundamental step in high-throughput sequencing analysis is the alignment (mapping) of the generated reads to a reference sequence. To accomplish this task numerous software tools have been proposed. Determining the mappers that are most suitable for a specific application is not trivial. Results: This survey focuses on classifying mappers through a wide number of characteristics. The goal is to allow practitioners to compare the mappers more easily and find those that are most suitable for their specific problem.
引用
收藏
页码:3169 / 3177
页数:9
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