Functionalmagneticresonanceimaging(fMRI)changesandsaliva production associated with acupuncture at LI-2 acupuncture point: a randomized controlled study

被引:59
作者
Deng, Gary [1 ]
Hou, Bob L. [2 ]
Holodny, Andrei I. [2 ]
Cassileth, Barrie R. [1 ]
机构
[1] Mem Sloan Kettering Canc Ctr, Integrat Med Serv, New York, NY 10021 USA
[2] Mem Sloan Kettering Canc Ctr, Funct MRI Lab, New York, NY 10021 USA
来源
BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE | 2008年 / 8卷 / 1期
关键词
D O I
10.1186/1472-6882-8-37
中图分类号
R [医药、卫生];
学科分类号
10 ;
摘要
Background: Clinical studies suggest that acupuncture can stimulate saliva production and reduce xerostomia (dry mouth). We were interested in exploring the neuronal substrates involved in such responses. Methods: In a randomized, sham acupuncture controlled, subject blinded trial, twenty healthy volunteers received true and sham acupuncture in random order. Cortical regions that were activated or deactivated during the interventions were evaluated by functional magnetic resonance imaging (fMRI). Saliva production was also measured. Results: Unilateral manual acupuncture stimulation at LI-2, a point commonly used in clinical practice to treat xerostomia, was associated with bilateral activation of the insula and adjacent operculum. Sham acupuncture at an adjacent site induced neither activation nordeactivation. True acupuncture induced more saliva production than sham acupuncture. Conclusion: Acupuncture at LI-2 was associated with neuronal activations absent during sham acupuncture stimulation. Neuroimaging signal changes appear correlated to saliva production.
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页数:7
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共 38 条
[1]   Analgesic effect of auricular acupuncture for cancer pain:: A randomized, blinded, controlled trial [J].
Alimi, D ;
Rubino, C ;
Pichard-Léandri, E ;
Fermand-Brulé, S ;
Dubreuil-Lemaire, ML ;
Hill, C .
JOURNAL OF CLINICAL ONCOLOGY, 2003, 21 (22) :4120-4126
[2]   Human brain mechanisms of pain perception and regulation in health and disease [J].
Apkarian, AV ;
Bushnell, MC ;
Treede, RD ;
Zubieta, JK .
EUROPEAN JOURNAL OF PAIN, 2005, 9 (04) :463-484
[3]   PROCESSING STRATEGIES FOR TIME-COURSE DATA SETS IN FUNCTIONAL MRI OF THE HUMAN BRAIN [J].
BANDETTINI, PA ;
JESMANOWICZ, A ;
WONG, EC ;
HYDE, JS .
MAGNETIC RESONANCE IN MEDICINE, 1993, 30 (02) :161-173
[4]   Effectiveness of acupuncture as adjunctive therapy in osteoarthritis of the knee - A randomized, controlled trial [J].
Berman, BM ;
Lao, LX ;
Langenberg, P ;
Lee, WL ;
Gilpin, AMK ;
Hochberg, MC .
ANNALS OF INTERNAL MEDICINE, 2004, 141 (12) :901-910
[5]  
Blom M, 2000, ORAL DIS, V6, P15
[6]   Interaction of gustatory and lingual somatosensory perceptions at the cortical level in the human: a functional magnetic resonance imaging study [J].
Cerf-Ducastel, B ;
Ven de Moortele, PF ;
MacLeod, P ;
Le Bihan, D ;
Faurion, A .
CHEMICAL SENSES, 2001, 26 (04) :371-383
[7]   Parametric analysis of fMRI data using linear systems methods [J].
Cohen, MS .
NEUROIMAGE, 1997, 6 (02) :93-103
[8]   AFNI: Software for analysis and visualization of functional magnetic resonance neuroimages [J].
Cox, RW .
COMPUTERS AND BIOMEDICAL RESEARCH, 1996, 29 (03) :162-173
[9]  
Dawidson I, 1997, J ORAL REHABIL, V24, P204
[10]   Measurement of cortisol in small quantities of saliva [J].
de Weerth, C ;
Graat, G ;
Buitelaar, JK ;
Thijssen, JHH .
CLINICAL CHEMISTRY, 2003, 49 (04) :658-660