Proliferation of hepatic peroxisomes in rats following the intake of green or black tea

被引：9

作者：

Bu-Abbas, A ^{[1
]}

Dobrota, M ^{[1
]}

Copeland, E ^{[1
]}

Clifford, MN ^{[1
]}

Walker, R ^{[1
]}

Ioannides, C ^{[1
]}

机构：

[1] Univ Surrey, Sch Biol Sci, Guildford GU2 5XH, Surrey, England

来源：

TOXICOLOGY LETTERS | 1999年 / 109卷 / 1-2期

关键词：

green tea; black tea; peroxisomes; peroxisomal proliferation; flavonoids; cytochromes P450;

D O I：

10.1016/S0378-4274(99)00119-8

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Rats maintained on green, black or decaffeinated black tea (2.5%, w/v) as their sole drinking fluid displayed higher hepatic CN- insensitive palmitoyl CoA oxidase activity than controls, the extent of increase was similar with the three types of tea. Morphological examination of the liver using electron microscopy revealed an increase in the number of peroxisomes in the tea-treated animals. The same treatment of the animals with green and black tea resulted in a similar rise in hepatic microsomal lauric acid hydroxylation. Analysis by HPLC of the aqueous tea extracts employed in the current study showed that the total flavanol content of the green variety was much higher than the black varieties, and confirmed the absence of caffeine in the decaffeinated black tea. It may be concluded from the present studies that neither caffeine nor flavanoids are likely to be responsible for the proliferation of peroxisomes observed in rats treated with tea. (C) 1999 Published by Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：69 / 76

页数：8

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