Synthesis of Folic Acid Functionalized PLLA-b-PPEGMA Nanoparticles for Cancer Cell Targeting

被引：32

作者：

Hu, Feixiong ^{[1
]}

Neoh, Koon Gee ^{[1
]}

Kang, En-Tang ^{[1
]}

机构：

[1] Natl Univ Singapore, Dept Chem & Biomol Engn, Singapore 119260, Singapore

来源：

MACROMOLECULAR RAPID COMMUNICATIONS | 2009年 / 30卷 / 08期

关键词：

atom transfer radical polymerization (ATRP); folic acid; nanoparticles; poly(ethylene glycol); targeted delivery; TRANSFER RADICAL POLYMERIZATION; FOLATE RECEPTOR; IN-VITRO; MAGNETITE NANOPARTICLES; ANTICANCER DRUGS; CONTRAST AGENT; DELIVERY; DOXORUBICIN; COPOLYMERS; MICELLES;

D O I：

10.1002/marc.200800771

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 [高分子化学与物理];

摘要：

Poly(L-lactic acid)-block-poly(poly(ethylene glycol) monomethacrylate) (PLLA-b-PPEGMA) has been prepared by the ring-opening polymerization of lactide with a double-headed initiator, 2-hydroxyethyl 2'-methyl-2'bromopropionate (HMBP), followed by atom transfer radical polymerization (ATRP) of poly(ethylene glycol) monomethacrylate (PEGMA) PLLA-b-PPEGMA nanoparticles with encapsulated Fe3O4 are prepared by a solvent evaporation/extraction technique, and then further functionalized with folic acid, a cancer targeting ligand. Our results show that such functionalized PLLA-b-PPEGMA nanoparticles have good potential as carriers for targeted drug delivery in cancer treatment.

引用

页码：609 / 614

页数：6

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